VE 821

Name: VE 821
Brand: Tocris Bioscience
SKU: 6160

Tocris Bioscience, part of Bio-Techne | Catalog # 6160

COA / SDS

High affinity and selective ATP-competitive ATR inhibitor

Discontinued Product

6160 has been discontinued. View all ATM and ATR Kinase Inhibitors products.

Key Product Details

Description:	High affinity and selective ATP-competitive ATR inhibitor
Chemical Name:	3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	368.41

View Full Technical Details for VE 821

Technical Data
Citations

Biological Activity for VE 821

VE 821 is a high affinity and selective ATP-competitive ATR inhibitor (K_i = 13 nM). Exhibits >75-fold selectivity for ATR over related kinases mTOR, DNA-PK, PI 3-Kγ and PIKKs (K_i values are >1, 2.2, 3.9 and 16 μM, respectively) and a panel of other kinases. Induces cell death in colon cancer cell lines in vitro and sensitizes tumor cells to treatment with DNA damaging anticancer agents.

Technical Data for VE 821

M. Wt	368.41
Formula	C₁₈H₁₆N₄O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1232410-49-9
PubChem ID	51000408
InChi Key	DUIHHZKTCSNTGM-UHFFFAOYSA-N
Smiles	CS(=O)(C1=CC=C(C2=NC(C(NC3=CC=CC=C3)=O)=C(N=C2)N)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VE 821

References are publications that support the biological activity of the product.

Williamson ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A. Nat.Commun. 2016 PMID: 27958275
Reaper Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat.Chem.Biol. 2011 PMID: 21490603

VE 821

Tocris Bioscience, part of Bio-Techne | Catalog # 6160

Key Product Details

Biological Activity for VE 821

Technical Data for VE 821

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for VE 821

Product Documents for VE 821

COA

Certificate of Analysis

SDS

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