Urotensin II (human)

Name: Urotensin II (human)
Brand: Tocris Bioscience
SKU: 1642

Catalog # 1642 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

Endogenous vasoactive agonist for the UT receptor

Key Product Details

Description:	Endogenous vasoactive agonist for the UT receptor
Molecular Weight:	1388.57

View Full Technical Details for Urotensin II (human)

Technical Data
Citations / Reviews

Biological Activity for Urotensin II (human)

Urotensin II (human) is a potent endogenous peptide agonist for the urotensin-II receptor (EC₅₀ = 0.1 nM). Displays arterio-selective vasoconstriction and vasodilatation in mammals in vitro and in vivo, effects which vary between species. Also has been shown to mediate bronchoconstriction.

Technical Data for Urotensin II (human)

M. Wt	1388.57
Formula	C₆₄H₈₅N₁₃O₁₈S₂
Single Letter Sequence	ETPDCFWKYCV (Modifications: Disulfide bridge between 5 - 10)
Storage	Desiccate at -20°C
CAS Number	251293-28-4
PubChem ID	46225600
InChi Key	HFNHAPQMXICKCF-USJMABIRSA-N
Smiles	[H]N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Urotensin II (human)

Solubility

Soluble to 1mg/ml in water

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References for Urotensin II (human)

References are publications that support the biological activity of the product.

Maguire and Davenport Is urotensin-II the new endothelin? Br.J.Pharmacol 2002 PMID: 12381671
Nothacker Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction. Nat.Cell.Biol. 1999 PMID: 10559967
Coulouarn Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurones of the spinal cord. Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9861051

Citations for Urotensin II (human)

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