Urapidil hydrochloride

Name: Urapidil hydrochloride
Brand: Tocris Bioscience
SKU: 1772

Tocris Bioscience a Bio-Techne Brand

Catalog # 1772

COA / SDS

Discontinued Product

1772 has been discontinued. View all Adrenergic alpha-1 Receptor Antagonists products.

Key Product Details

Description:	α₁ antagonist; also 5-HT_1A receptor agonist
Chemical Name:	6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	423.94

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Biological Activity for Urapidil hydrochloride

Urapidil hydrochloride is an α₁-adrenoceptor antagonist and 5-HT_1A receptor agonist (pIC₅₀ values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.

Technical Data for Urapidil hydrochloride

M. Wt	423.94
Formula	C₂₀H₂₉N₅O₃.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	64887-14-5
PubChem ID	167980
InChi Key	KTMLZVUAXJERAT-UHFFFAOYSA-N
Smiles	Cl.COC1=CC=CC=C1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Urapidil hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	21.2	50

Preparing Stock Solutions for Urapidil hydrochloride

The following data is based on the product molecular weight 423.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.72 mL	23.59 mL	47.18 mL
2.5 mM	0.94 mL	4.72 mL	9.44 mL
5 mM	0.47 mL	2.36 mL	4.72 mL
25 mM	0.09 mL	0.47 mL	0.94 mL

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References for Urapidil hydrochloride

References are publications that support the biological activity of the product.

Kolassa Involvement of brain 5-HT_1A receptors in the hypotensive response to urapidil. Am.J.Cardiol. 1989 PMID: 2569265
van Zwieten PA Pharmacologic profile of urapidil. Am.J.Cardiol. 1989 PMID: 2569262
Gross Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT_1A subtype and for α₁-adrenoceptor binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 1987 PMID: 2832770

Citations for Urapidil hydrochloride

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