UAMC 00039 dihydrochloride

Name: UAMC 00039 dihydrochloride
Brand: Tocris Bioscience
SKU: 4954

Tocris Bioscience a Bio-Techne Brand

Catalog # 4954

Citations (1)

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Key Product Details

Description:	Dipeptidyl peptidase II (DPP-II) inhibitor
Chemical Name:	(2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	382.76

View Full Technical Details for UAMC 00039 dihydrochloride

Biological Activity for UAMC 00039 dihydrochloride

UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC₅₀ = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC₅₀ values are 78.6, 142 and 165 μM, respectively). Orally available.

Technical Data for UAMC 00039 dihydrochloride

M. Wt	382.76
Formula	C₁₆H₂₄ClN₃O.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	697797-51-6
PubChem ID	24757888
InChi Key	IWXMOQGMIWZNPR-CKUXDGONSA-N
Smiles	O=C([C@@H](N)CCNCC2=CC=C(Cl)C=C2)N1CCCCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UAMC 00039 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	38.28	100
	DMSO	38.28	100

Preparing Stock Solutions for UAMC 00039 dihydrochloride

The following data is based on the product molecular weight 382.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.06 mL	26.13 mL
5 mM	0.52 mL	2.61 mL	5.23 mL
10 mM	0.26 mL	1.31 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for UAMC 00039 dihydrochloride

References are publications that support the biological activity of the product.

Van Goethem Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? J.Med.Chem. 2011 PMID: 21711053
Maes Dipeptidyl peptidase 8/9-like activity in human leukocytes. J.Leukoc.Biol. 2007 PMID: 17287297

Citations for UAMC 00039 dihydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for UAMC 00039 dihydrochloride include:

Klein et al. (2017) Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. Neuron. 95:281
PMID: 28728022

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