U 104

Name: U 104
Brand: Tocris Bioscience
SKU: 4540

Tocris Bioscience a Bio-Techne Brand

Catalog # 4540

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Key Product Details

Description:	Potent carbonic anhydrase (CA) IX and XII inhibitor
Chemical Name:	4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	309.32

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Biological Activity for U 104

U 104 is a potent carbonic anhydrase (CA) inhibitor (K_i values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). Inhibits tumor metastasis in the rat 4T1 metastasis model.

Compound Libraries for U 104

U 104 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for U 104

M. Wt	309.32
Formula	C₁₃H₁₂FN₃O₃S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	178606-66-1
PubChem ID	310360
InChi Key	YJQZNWPYLCNRLP-UHFFFAOYSA-N
Smiles	FC1=CC=C(NC(NC2=CC=C(S(=O)(N)=O)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for U 104

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.93	100

Preparing Stock Solutions for U 104

The following data is based on the product molecular weight 309.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.23 mL	16.16 mL	32.33 mL
5 mM	0.65 mL	3.23 mL	6.47 mL
10 mM	0.32 mL	1.62 mL	3.23 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

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References for U 104

References are publications that support the biological activity of the product.

Lou Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011 PMID: 21415165

Citations for U 104

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