Tracazolate hydrochloride

Name: Tracazolate hydrochloride
Brand: Tocris Bioscience
SKU: 1558

Catalog # 1558 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Allosteric modulator of GABAA receptors

Key Product Details

Description:	Allosteric modulator of GABA_A receptors
Alternative Names:	ICI 136753
Chemical Name:	4-(Butylamino)-1-ethyl-6-methyl 1H-pyrazolo[3,4b]pyridine-5-ethylcarboxylate hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	340.85

View Full Technical Details for Tracazolate hydrochloride

Technical Data
Citations (1) / Reviews

Biological Activity for Tracazolate hydrochloride

Tracazolate hydrochloride is a GABA_A receptor modulator. Can potentiate or inhibit recombinant GABA_A function depending on subunit combination. Enhances native GABA_A receptor function and is anxiolytic following systemic administration in vivo.

Technical Data for Tracazolate hydrochloride

M. Wt	340.85
Formula	C₁₆H₂₄N₄O₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1135210-68-2
PubChem ID	24871267
InChi Key	TUIXDPUEMQXVHO-UHFFFAOYSA-N
Smiles	Cl.CCCCNC1=C2C=NN(CC)C2=NC(C)=C1C(=O)OCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tracazolate hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. HCl	34.09	100

Preparing Stock Solutions for Tracazolate hydrochloride

The following data is based on the product molecular weight 340.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.67 mL	29.34 mL
5 mM	0.59 mL	2.93 mL	5.87 mL
10 mM	0.29 mL	1.47 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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Reconstitution Calculator

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References for Tracazolate hydrochloride

References are publications that support the biological activity of the product.

Thompson Tracazolate reveals a novel type of allosteric interaction with recombinant γ-aminobutyric acid_A receptors. Mol.Pharmacol. 2002 PMID: 11901225
Meiners and Salama Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate. Eur.J.Pharmacol. 1982 PMID: 6121710
Patel and Malick Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur.J.Pharmacol. 1982 PMID: 6121711

Citations for Tracazolate hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for Tracazolate hydrochloride include:

Kerti-Szigeti et al. (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Neurosci. 34:10219
PMID: 25080584

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