THPN

Name: THPN
Brand: Tocris Bioscience
SKU: 6017

Tocris Bioscience a Bio-Techne Brand

Catalog # 6017

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Key Product Details

Description:	Nur77 agonist; induces autophagy in melanoma cell lines
Chemical Name:	1-(3,4,5-Trihydroxyphenyl)-1-nonanone
Purity:	≥98% (HPLC)
Molecular Weight:	266.33

View Full Technical Details for THPN

Biological Activity for THPN

THPN is a Nur77 agonist. Binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.

Technical Data for THPN

M. Wt	266.33
Formula	C₁₅H₂₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	100079-26-3
PubChem ID	3063200
InChi Key	NVFRHTFJDGAFQS-UHFFFAOYSA-N
Smiles	CCCCCCCCC(C1=CC(O)=C(C(O)=C1)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for THPN

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.63	100
	ethanol	26.63	100

Preparing Stock Solutions for THPN

The following data is based on the product molecular weight 266.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.77 mL	37.55 mL
5 mM	0.75 mL	3.75 mL	7.51 mL
10 mM	0.38 mL	1.88 mL	3.75 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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References for THPN

References are publications that support the biological activity of the product.

Li Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 2015 PMID: 25822914
Wang Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 2014 PMID: 24316735

Citations for THPN

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