Thiostrepton

Name: Thiostrepton
Brand: Tocris Bioscience
SKU: 3267
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3267

(1)

Citations (39)

COA / SDS

Antibiotic, inhibits protein synthesis

Discontinued Product

3267 has been discontinued. View all Antibiotics products.

Key Product Details

Description:	Antibiotic, inhibits protein synthesis
Purity:	≥90% (HPLC)
Molecular Weight:	1664.89

View Full Technical Details for Thiostrepton

Technical Data
Citations / Reviews (1)

Biological Activity for Thiostrepton

Thiostrepton is an antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.

Technical Data for Thiostrepton

M. Wt	1664.89
Formula	C₇₂H₈₅N₁₉O₁₈S₅
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	1393-48-2
PubChem ID	16129666
InChi Key	NSFFHOGKXHRQEW-DVRIZHICSA-N
Smiles	C=C(C(NC(C(N)=O)=C)=O)NC(C1=CSC(C2=NC(C3=CSC(C(C(C)OC(C4=CC(C(C)O)=C(C=CC(NC(C(NC(C)C(NC(C(NC(C)C5=O)=O)=C)=O)=O)C(C)CC)C6O)C6=N4)=O)N7)=N3)C(CC2)(N5)C8=NC(C(NC(C(N/C(C9=NC(C(NC(C(O)(C)C(C)O)C%10=NC(C7=O)=CS%10)=O)CS9)=C/C)=O)C(O)C)=O)=CS8)=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Thiostrepton

References are publications that support the biological activity of the product.

Kwok Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Mol.Cancer Ther. 2008 PMID: 18645012
Rodnina Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc.Natl.Acad.Sci.USA
Ruben Thiostrepton inhibition of tRNA delivery to the ribosome. RNA 2007 PMID: 17951333

Thiostrepton

Tocris Bioscience, part of Bio-Techne | Catalog # 3267

Key Product Details

Biological Activity for Thiostrepton

Technical Data for Thiostrepton

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Thiostrepton

Product Documents for Thiostrepton

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected