tcY-NH₂

Name: tcY-NH 2
Brand: Tocris Bioscience
SKU: 1488

Tocris Bioscience, part of Bio-Techne | Catalog # 1488

Citations (17)

COA / SDS

Selective PAR4 antagonist

Discontinued Product

1488 has been discontinued. View all Protease-Activated Receptor Antagonists products.

Key Product Details

Description:	Selective PAR₄ antagonist
Alternative Names:	(trans-Cinnamoyl)-YPGKF-NH₂
Purity:	≥95% (HPLC)
Molecular Weight:	739.87

View Full Technical Details for tcY-NH₂

Technical Data
Citations

Biological Activity for tcY-NH₂

tcY-NH₂ is a selective PAR₄ antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.

Technical Data for tcY-NH₂

M. Wt	739.87
Formula	C₄₀H₄₉N₇O₇
Single Letter Sequence	YPGKF (Modifications: Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	327177-34-4
PubChem ID	11479675
InChi Key	XKRAKQXQVIGYQC-PHOSSJRVSA-N
Smiles	NCCCC[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)\C=C\C1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for tcY-NH₂

References are publications that support the biological activity of the product.

Hollenberg and Saifeddine Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 2001 PMID: 11405248
Ma Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br.J.Pharmacol. 2001 PMID: 11606309
Hollenberg Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 2004 PMID: 15451771

tcY-NH₂

Tocris Bioscience, part of Bio-Techne | Catalog # 1488

Key Product Details

Biological Activity for tcY-NH₂

Technical Data for tcY-NH₂

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for tcY-NH₂

Product Documents for tcY-NH₂

COA

Certificate of Analysis

SDS

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tcY-NH2

Tocris Bioscience, part of Bio-Techne | Catalog # 1488

Key Product Details

Biological Activity for tcY-NH2

Technical Data for tcY-NH2

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for tcY-NH2

Product Documents for tcY-NH2

COA

Certificate of Analysis

SDS

tcY-NH₂

Biological Activity for tcY-NH₂

Technical Data for tcY-NH₂

References for tcY-NH₂

Product Documents for tcY-NH₂