TCS PrP Inhibitor 13

Name: TCS PrP Inhibitor 13
Brand: Tocris Bioscience
SKU: 3238

Tocris Bioscience a Bio-Techne Brand

Catalog # 3238

Citations (2)

COA / SDS

Discontinued Product

3238 has been discontinued. View all Neuronal Metabolism Peptides and Compounds products.

Key Product Details

Description:	Antiprion agent; inhibits PrP^Sc accumulation
Chemical Name:	2,4-Dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one
Purity:	≥98% (HPLC)
Molecular Weight:	281.27

View Full Technical Details for TCS PrP Inhibitor 13

Biological Activity for TCS PrP Inhibitor 13

TCS PrP Inhibitor 13 is an antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC₅₀ = 3 nM). Also reduces PrP expression and decreases proliferation and survival in schwannoma cell lines.

Technical Data for TCS PrP Inhibitor 13

M. Wt	281.27
Formula	C₁₅H₁₁N₃O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	34320-83-7
PubChem ID	2750328
InChi Key	FDAVFKZPGQEGDX-UHFFFAOYSA-N
Smiles	O=C(C2)N(C3=CC=CC=C3)N=C2C1=CC=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS PrP Inhibitor 13

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.13	100
	ethanol	7.03	25

Preparing Stock Solutions for TCS PrP Inhibitor 13

The following data is based on the product molecular weight 281.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.56 mL	17.78 mL	35.55 mL
5 mM	0.71 mL	3.56 mL	7.11 mL
10 mM	0.36 mL	1.78 mL	3.56 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

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References for TCS PrP Inhibitor 13

References are publications that support the biological activity of the product.

Provenzano Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 2017 PMID: 28692055
Kimata New series of antiprion compounds: pyrazolone derivatives have potent activity of inhibiting protease-resistant prion protein accumulation. J.Med.Chem. 2007 PMID: 17850126

Citations for TCS PrP Inhibitor 13 (2)

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Citations are publications that use Bio-Techne products. Selected citations for TCS PrP Inhibitor 13 include:

Safavifar et al. (2019) Augmented cAMP Signaling by Co-Administration of Resveratrol and Curcumin: A Cellular Biosensor Kinetic Assessment. Iran J Public Health. 48:1310
PMID: 31497553
Provenzano et al. (2017) Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene.. 2017;
PMID: 28692055

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