TCPOBOP

Name: TCPOBOP
Brand: Tocris Bioscience
SKU: 1225

Tocris Bioscience, part of Bio-Techne | Catalog # 1225

COA / SDS

Constitutive androstane receptor agonist

Discontinued Product

1225 has been discontinued. View all VDR-like Receptor Agonists products.

Key Product Details

Description:	Constitutive androstane receptor agonist
Chemical Name:	1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene
Purity:	≥98% (HPLC)
Molecular Weight:	402.06

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Technical Data
Citations

Biological Activity for TCPOBOP

TCPOBOP is an agonist of the constitutive androstane receptor (CAR) (EC₅₀ = 20 nM). Induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice.

Technical Data for TCPOBOP

M. Wt	402.06
Formula	C₁₆H₈Cl₄N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	76150-91-9
PubChem ID	5382
InChi Key	BAFKRPOFIYPKBQ-UHFFFAOYSA-N
Smiles	ClC(C=N3)=CC(Cl)=C3OC(C=C2)=CC=C2OC1=NC=C(Cl)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TCPOBOP

References are publications that support the biological activity of the product.

Poland 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity. Mol.Pharmacol. 1980 PMID: 7464820
Tzameli The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol.Cell.Biol. 2000 PMID: 10757780
Ledda-Columbano In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway. Oncogene 1998 PMID: 9747883

TCPOBOP

Tocris Bioscience, part of Bio-Techne | Catalog # 1225

Key Product Details

Biological Activity for TCPOBOP

Technical Data for TCPOBOP

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TCPOBOP

Product Documents for TCPOBOP

COA

Certificate of Analysis

SDS

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