TCN 238

Name: TCN 238
Brand: Tocris Bioscience
SKU: 4259

Tocris Bioscience, part of Bio-Techne | Catalog # 4259

Citations (14)

COA / SDS

Positive allosteric modulator of mGlu4 receptors

Discontinued Product

4259 has been discontinued. View all Group III mGluR Modulators products.

Key Product Details

Description:	Positive allosteric modulator of mGlu₄ receptors
Chemical Name:	(E)-4-(2-Phenylethenyl)-2-pyrimidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	197.24

View Full Technical Details for TCN 238

Technical Data
Citations

Biological Activity for TCN 238

TCN 238 is a positive allosteric modulator of mGlu₄ receptors (EC₅₀ = 1.0 μM for human and rat mGlu₄ receptors). Orally available and brain penetrant.

Technical Data for TCN 238

M. Wt	197.24
Formula	C₁₂H₁₁N₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	125404-04-8
PubChem ID	46911068
InChi Key	LNUXNUNUGIHCPA-VOTSOKGWSA-N
Smiles	NC1=NC(/C=C/C2=CC=CC=C2)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TCN 238

References are publications that support the biological activity of the product.

East An orally bioavailable positive allosteric modulator of the mGlu₄ receptor with efficacy in an animal model of motor dysfunction. Bioorg.Med.Chem.Lett. 2010 PMID: 20638279

TCN 238

Tocris Bioscience, part of Bio-Techne | Catalog # 4259

Key Product Details

Biological Activity for TCN 238

Technical Data for TCN 238

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TCN 238

Product Documents for TCN 238

COA

Certificate of Analysis

SDS

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