Tautomycetin

Name: Tautomycetin
Brand: Tocris Bioscience
SKU: 2305

Tocris Bioscience a Bio-Techne Brand

Catalog # 2305

Citations (17)

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Key Product Details

Description:	Selective PP1 inhibitor
Chemical Name:	(1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester
Purity:	≥95% (HPLC)
Molecular Weight:	606.75

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Technical Data
Citations (17) / Reviews

Biological Activity for Tautomycetin

Tautomycetin is a selective inhibitor of protein phosphatase (PP)1 (IC₅₀ values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.

Technical Data for Tautomycetin

M. Wt	606.75
Formula	C₃₃H₅₀O₁₀
Storage	Desiccate at -20°C
Purity	≥95% (HPLC)
CAS Number	119757-73-2
PubChem ID	16759609
InChi Key	VAIBGAONSFVVKI-CIFLJJJCSA-N
Smiles	O=C(O1)C([C@H](O)CC(O[C@H](C)[C@@H](C)[C@H](O)CC([C@@H](C)[C@@H](O)CC[C@H](C)C[C@@H](C)CC(/C=C(CC)/C=C)=O)=O)=O)=C(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tautomycetin

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Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

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References for Tautomycetin

References are publications that support the biological activity of the product.

Kim Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells. Transplant Proc. 2005 PMID: 15919517
Shim Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc.Natl.Acad.Sci.USA. 2002 PMID: 12149481
Mitsuhashi Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. Biochem.Biophys.Res.Comm. 2001 PMID: 11554729

Citations for Tautomycetin (17)

Showing 1 - 10 of 17 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Tautomycetin include:

Garzón et al. (2019) Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling. Cell Rep. 27:2558
PMID: 31141682
Messal et al. (2019) Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. Nature. 566:126
PMID: 30700911
Liu (2018) In vivo brain GPCR signaling elucidated by phosphoproteomics. Science. 360(6395):eaao4927
PMID: 29930108
Georgilis et al. (2018) PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell. 34:85
PMID: 29990503
Wan et al. (2018) M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation. Front Mol Neurosci. 11:287
PMID: 30186110
Pyo et al. (2018) ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation. Cell Rep. 25:2878
PMID: 30517873
Alver et al. (2017) Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1. Cell Rep. 18:2508
PMID: 28273463
Hiraga et al. (2017) Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation. EMBO Rep. 18:403
PMID: 28077461
Engmann et al. (2015) DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nat Commun. 6:10099
PMID: 26639316
Isensee et al. (2014) Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci. 127:216
PMID: 24190886
Mirante et al. (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. PLoS Genet. 7:62
PMID: 25071439
Hégarat et al. (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. Anticancer Res. 10:e1004004
PMID: 24391510
Huang et al. (2014) PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF. Am J Physiol Cell Physiol. 306:C167
PMID: 24196533
Pribiag and Stellwagen (2013) TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors. Front Neurosci. 33:15879
PMID: 24089494
Toledo et al. (2013) A novel effect of MARCKS phosphorylation by activated PKC: the dephosphorylation of its serine 25 in chick neuroblasts. PLoS One. 8:e62863
PMID: 23634231
Walsh and Young (2011) TGF-β regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1. Anticancer Res. 31:3159
PMID: 21965722
Walsh and Young (2010) Interrelationship between protein phosphatase 1 and TGF-{β} in regulating motility and cytoskeletal architecture of endothelial cells. J Neurosci. 30:4861
PMID: 21187463

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