Tautomycetin

Name: Tautomycetin
Brand: Tocris Bioscience
SKU: 2305

Tocris Bioscience, part of Bio-Techne | Catalog # 2305

Citations (18)

COA / SDS

Selective PP1 inhibitor

Discontinued Product

2305 has been discontinued. View all Protein Ser/Thr Phosphatase Inhibitors products.

Key Product Details

Description:	Selective PP1 inhibitor
Chemical Name:	(1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester
Purity:	≥95% (HPLC)
Molecular Weight:	606.75

View Full Technical Details for Tautomycetin

Technical Data
Citations

Biological Activity for Tautomycetin

Tautomycetin is a selective inhibitor of protein phosphatase (PP)1 (IC₅₀ values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.

Technical Data for Tautomycetin

M. Wt	606.75
Formula	C₃₃H₅₀O₁₀
Storage	Desiccate at -20°C
Purity	≥95% (HPLC)
CAS Number	119757-73-2
PubChem ID	16759609
InChi Key	VAIBGAONSFVVKI-CIFLJJJCSA-N
Smiles	O=C(O1)C([C@H](O)CC(O[C@H](C)[C@@H](C)[C@H](O)CC([C@@H](C)[C@@H](O)CC[C@H](C)C[C@@H](C)CC(/C=C(CC)/C=C)=O)=O)=O)=C(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Tautomycetin

References are publications that support the biological activity of the product.

Shim Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc.Natl.Acad.Sci.USA. 2002 PMID: 12149481
Kim Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells. Transplant Proc. 2005 PMID: 15919517
Mitsuhashi Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. Biochem.Biophys.Res.Comm. 2001 PMID: 11554729

Tautomycetin

Tocris Bioscience, part of Bio-Techne | Catalog # 2305

Key Product Details

Biological Activity for Tautomycetin

Technical Data for Tautomycetin

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Tautomycetin

Product Documents for Tautomycetin

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected