SU 9516

Name: SU 9516
Brand: Tocris Bioscience
SKU: 2907

Tocris Bioscience, part of Bio-Techne | Catalog # 2907

Citations (2)

COA / SDS

Cdk inhibitor; potently inhibits cdk1 and cdk2

Discontinued Product

2907 has been discontinued. View all Cyclin-dependent Kinase Inhibitors products.

Key Product Details

Description:	Cdk inhibitor; potently inhibits cdk1 and cdk2
Chemical Name:	(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one
Purity:	≥99% (HPLC)
Molecular Weight:	241.25

View Full Technical Details for SU 9516

Technical Data
Citations

Biological Activity for SU 9516

SU 9516 is a cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.02 - 0.03, 0.04 - 0.2, 0.2 - 1.7 and 0.9 μM for cdk2, cdk1, cdk4 and cdk9, respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and pro-apoptotic effects in vitro.

Technical Data for SU 9516

M. Wt	241.25
Formula	C₁₃H₁₁N₃O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	377090-84-1
PubChem ID	5289419
InChi Key	QNUKRWAIZMBVCU-WCIBSUBMSA-N
Smiles	O=C2NC1=CC=C(OC)C=C1/C2=C/C3=CNC=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SU 9516

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem 2018 PMID: 30234987
Yu SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells. Biochem.Pharmacol. 2002 PMID: 12234612
Gao The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional m Mol.Pharmacol. 2006 PMID: 16672643
Lane A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells. Cancer Res. 2001 PMID: 11507069

SU 9516

Tocris Bioscience, part of Bio-Techne | Catalog # 2907

Key Product Details

Biological Activity for SU 9516

Technical Data for SU 9516

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for SU 9516

Product Documents for SU 9516

COA

Certificate of Analysis

SDS

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