SU 9516

Name: SU 9516
Brand: Tocris Bioscience
SKU: 2907

Tocris Bioscience a Bio-Techne Brand

Catalog # 2907

Citations (2)

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Key Product Details

Description:	Cdk inhibitor; potently inhibits cdk1 and cdk2
Chemical Name:	(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one
Purity:	≥99% (HPLC)
Molecular Weight:	241.25

View Full Technical Details for SU 9516

Biological Activity for SU 9516

SU 9516 is a cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.02 - 0.03, 0.04 - 0.2, 0.2 - 1.7 and 0.9 μM for cdk2, cdk1, cdk4 and cdk9, respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and pro-apoptotic effects in vitro.

Compound Libraries for SU 9516

SU 9516 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SU 9516

M. Wt	241.25
Formula	C₁₃H₁₁N₃O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	377090-84-1
PubChem ID	5289419
InChi Key	QNUKRWAIZMBVCU-WCIBSUBMSA-N
Smiles	O=C2NC1=CC=C(OC)C=C1/C2=C/C3=CNC=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SU 9516

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.12	100
	ethanol	4.83	20

Preparing Stock Solutions for SU 9516

The following data is based on the product molecular weight 241.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.15 mL	20.73 mL	41.45 mL
5 mM	0.83 mL	4.15 mL	8.29 mL
10 mM	0.41 mL	2.07 mL	4.15 mL
50 mM	0.08 mL	0.41 mL	0.83 mL

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References for SU 9516

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem 2018 PMID: 30234987
Gao The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional m Mol.Pharmacol. 2006 PMID: 16672643
Yu SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells. Biochem.Pharmacol. 2002 PMID: 12234612
Lane A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells. Cancer Res. 2001 PMID: 11507069

Citations for SU 9516 (2)

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Citations are publications that use Bio-Techne products. Selected citations for SU 9516 include:

Pollet et al. (2018) The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Cell Death Differ. 25:1823
PMID: 30013037
Shi et al. (2014) The FGF-1-specific single-chain antibody scFv1C9 effectively inhibits breast cancer tumour growth and metastasis. J Cell Mol Med. 18:2061
PMID: 25124967

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