STK16-IN-1

Name: STK16-IN-1
Brand: Tocris Bioscience
SKU: 6036

Tocris Bioscience, part of Bio-Techne | Catalog # 6036

COA / SDS

Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits PI 3Kδ, PI 3Kγ and mTOR kinases

Discontinued Product

6036 has been discontinued. View all Other Kinase Inhibitors products.

Key Product Details

Description:	Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits PI 3Kδ, PI 3Kγ and mTOR kinases
Chemical Name:	1-(4-Fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	293.3

View Full Technical Details for STK16-IN-1

Technical Data
Citations

Biological Activity for STK16-IN-1

STK16-IN-1 is a serine/threonine protein kinase 16 (STK16) inhibitor (IC₅₀ = 295 nM). Reduces cell number and increases accumulation of binucleated MCF-1 cells. Enhances cell apoptosis in combination with chemotherapeutics. Also inhibits PI 3-Kδ and PI-3-Kγ kinases (IC₅₀ values are 856 and 867 nM, respectively) and mTOR kinase (IC₅₀= 5.56 μM).

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Technical Data for STK16-IN-1

M. Wt	293.3
Formula	C₁₇H₁₂FN₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1223001-53-3
PubChem ID	58525066
InChi Key	WQNRDXHKVSKUPI-UHFFFAOYSA-N
Smiles	O=C(N1C2=CC(C)=C(F)C=C2)C=CC3=C1C(C=CN4)=C4N=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for STK16-IN-1

References are publications that support the biological activity of the product.

Liu Discovery of a highly selective STK16 kinase inhibitor ACS.Chem.Biol. 2016 PMID: 27082499