SMANT hydrochloride

Name: SMANT hydrochloride
Brand: Tocris Bioscience
SKU: 4662

Tocris Bioscience, part of Bio-Techne | Catalog # 4662

COA / SDS

Inhibits Smoothened (Smo) accumulation

Discontinued Product

4662 has been discontinued. View all Other Smoothened Receptor Compounds products.

Key Product Details

Description:	Inhibits Smoothened (Smo) accumulation
Chemical Name:	N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	375.73

View Full Technical Details for SMANT hydrochloride

Technical Data
Citations

Biological Activity for SMANT hydrochloride

SMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC₅₀ = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.

Technical Data for SMANT hydrochloride

M. Wt	375.73
Formula	C₁₆H₂₃BrN₂O.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1177600-74-6
PubChem ID	2900213
InChi Key	XQESCHFXROUCOQ-UHFFFAOYSA-N
Smiles	BrC1=CC=C(NC(CCN2CC(C)CC(C)C2)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SMANT hydrochloride

References are publications that support the biological activity of the product.

Wang Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation. ACS Chem.Biol. 2012 PMID: 22554036

SMANT hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4662

Key Product Details

Biological Activity for SMANT hydrochloride

Technical Data for SMANT hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for SMANT hydrochloride

Product Documents for SMANT hydrochloride

COA

Certificate of Analysis

SDS

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