SKF 83822 hydrobromide

Name: SKF 83822 hydrobromide
Brand: Tocris Bioscience
SKU: 2075

Catalog # 2075 | Tocris Bioscience a Bio-Techne Brand

Citations (3)

COA / SDS

Selective D1-like agonist

Key Product Details

Description:	Selective D₁-like agonist
Chemical Name:	6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	424.76

View Full Technical Details for SKF 83822 hydrobromide

Technical Data
Citations (3) / Reviews

Biological Activity for SKF 83822 hydrobromide

SKF 83822 hydrobromide is a high affinity, selective dopamine D₁-like receptor agonist. K_i values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D₁, D₅, D₂, D₃, D₄, 5-HT_2A, α_1A and α_1B receptors respectively. Stimulates adenylyl cyclase (EC₅₀ = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.

Technical Data for SKF 83822 hydrobromide

M. Wt	424.76
Formula	C₂₀H₂₂ClNO₂.HBr
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	74115-10-9
PubChem ID	12909789
InChi Key	CFWPKYBBXBANLU-UHFFFAOYSA-N
Smiles	ClC1=C(O)C(O)=CC2=C1CCN(CC=C)CC2C3=CC=CC(C)=C3.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKF 83822 hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	3.44	10
	DMSO	34.38	100

Preparing Stock Solutions for SKF 83822 hydrobromide

The following data is based on the product molecular weight 424.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.77 mL	23.54 mL
5 mM	0.47 mL	2.35 mL	4.71 mL
10 mM	0.24 mL	1.18 mL	2.35 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for SKF 83822 hydrobromide

References are publications that support the biological activity of the product.

O'Sullivan SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled D1-like receptors: behavioural topography. Eur.J.Pharmacol. 2004 PMID: 14985049
Peacock and Gerlach Aberrant behavioural effects of a DA D1 receptor antagonist and agonist in monkeys: evidence of uncharted DA D1 receptor actions. Biol.Psychiatry 2001 PMID: 11600103
Undie Evidence for a distinct D₁-like DA receptor that couples to activation of phosphoinositide metabolism in brain. J.Neurochem. 1994 PMID: 7908949

Citations for SKF 83822 hydrobromide (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SKF 83822 hydrobromide include:

Kramar et al. (2014) DA in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory. J Neurosci. 39:1645
PMID: 24442095
Ruskin et al. (2013) Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One. 8:e65021
PMID: 23755170
Urizar et al. (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Neuropsychopharmacology. 7:624
PMID: 21785426

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