SGI 1027

Name: SGI 1027
Brand: Tocris Bioscience
SKU: 5155

Tocris Bioscience, part of Bio-Techne | Catalog # 5155

Citations (3)

COA / SDS

DNA methyltransferase inhibitor

Discontinued Product

5155 has been discontinued. View all DNA Methyltransferase Inhibitors products.

Key Product Details

Description:	DNA methyltransferase inhibitor
Chemical Name:	N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	461.52

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Technical Data
Citations

Biological Activity for SGI 1027

SGI 1027 is a DNA methyltransferase inhibitor. Inhibits the mammalian DNA methyltransferases DNMT3B, DNMT3A and DNMT1 (IC₅₀ values are 7.5, 8 and 12.5 μM with Poly(dl-dC) as the substrate). Reactivates silenced tumor suppressor genes by reducing CpG island hypermethylation.

Technical Data for SGI 1027

M. Wt	461.52
Formula	C₂₇H₂₃N₇O
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1020149-73-8
PubChem ID	24858111
InChi Key	QSYLKMKIVWJAAK-UHFFFAOYSA-N
Smiles	O=C(NC4=CC=C(NC5=NC(N)=NC(C)=C5)C=C4)C(C=C3)=CC=C3NC2=CC=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SGI 1027

References are publications that support the biological activity of the product.

García-Domínguez Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line. Bioorg.Med.Chem.Lett. 2013 PMID: 23402879
Datta A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer Res. 2009 PMID: 19417133

SGI 1027

Tocris Bioscience, part of Bio-Techne | Catalog # 5155

Key Product Details

Biological Activity for SGI 1027

Technical Data for SGI 1027

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for SGI 1027

Product Documents for SGI 1027

COA

Certificate of Analysis

SDS

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