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SCH 23390 hydrochloride

Dopamine D1 and D5 Receptor Antagonists Small Molecule
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0925/10
0925/50

Key Product Details

Description: Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
Alternative Names: (R)-(+)-SCH 23390 hydrochloride
Chemical Name: (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
Purity: ≥98% (HPLC)
Molecular Weight: 324.24

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Citations (58)

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  • Dopamine receptor antagonism
    Name: Sergiy Sylantyev
    Species: Human
    Cell Line/Tissue: Stem cell - derived neurons
    SCH‐23390 was in use as a dopamine receptor antagonist. Being applied at stem cell – derived cultured neurons (10 nM concentration) together with sulpiride, caused an increase of amplitudes of evoked post-synaptic potentials generated by NMDA receptors (see illustration). Preparation of 10 mM water stocks requires sonication.
    SCH 23390 hydrochloride Serum 0925
  • Effects of SCH 23390 on cue-induced reinstatement of food seeking
    Name: Kevin Ball
    Species: Rat
    Assay Type: In Vivo
    At a dose that did not alter responding during food self-administration (6 micrograms/kg), systemic injections of SCH 23390 blocked responding during cue-induced reinstatement of food seeking tests.
    SCH 23390 hydrochloride Serum 0925
  • A drug that affects locomotion
    Name: Luiz Alexandre Magno
    Species: Mouse
    Assay Type: In Vivo
    Our lab has used SCH23390 to block dopaminergic D1 receptors and to check its effect on locomotion. Mice were injected with this drug and we noticed that SCH23390 decreased the average speed during a 5-minute test.
    SCH 23390 hydrochloride Serum 0925

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