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SCH 23390 hydrochloride

Dopamine D1 and D5 Receptor Antagonists Small Molecule

Key Product Details

Description: Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
Alternative Names: (R)-(+)-SCH 23390 hydrochloride
Chemical Name: (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
Purity: ≥98% (HPLC)

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Citations (58)

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  • Dopamine receptor antagonism
    Name: Sergiy Sylantyev | 15th Oct 2020
    Species: Human
    Cell Line/Tissue: Stem cell - derived neurons
    SCH‐23390 was in use as a dopamine receptor antagonist. Being applied at stem cell – derived cultured neurons (10 nM concentration) together with sulpiride, caused an increase of amplitudes of evoked post-synaptic potentials generated by NMDA receptors (see illustration). Preparation of 10 mM water stocks requires sonication.
    Dopamine receptor antagonism Serum 0925
  • Effects of SCH 23390 on cue-induced reinstatement of food seeking
    Name: Kevin Ball | 22nd Jan 2019
    Species: Rat
    Assay Type: In Vivo
    At a dose that did not alter responding during food self-administration (6 micrograms/kg), systemic injections of SCH 23390 blocked responding during cue-induced reinstatement of food seeking tests.
    Effects of SCH 23390 on cue-induced reinstatement of food seeking Serum 0925
  • A drug that affects locomotion
    Name: Luiz Alexandre Magno | 26th Oct 2018
    Species: Mouse
    Assay Type: In Vivo
    Our lab has used SCH23390 to block dopaminergic D1 receptors and to check its effect on locomotion. Mice were injected with this drug and we noticed that SCH23390 decreased the average speed during a 5-minute test.
    A drug that affects locomotion Serum 0925

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