SCH 23390 hydrochloride
Catalog # 0925 | Tocris Bioscience a Bio-Techne Brand
Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
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Key Product Details
Description: | Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker |
Alternative Names: | (R)-(+)-SCH 23390 hydrochloride |
Chemical Name: | (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 324.24 |
Citations for SCH 23390 hydrochloride (59)
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Citations are publications that use Bio-Techne products. Selected citations for SCH 23390 hydrochloride include:
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Tsea et al.
(2023)
Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats.
Proc.Natl.Acad.Sci.U.S.A..
120:e2307275120
PMID: 37931094 -
Dorst et al.
(2020)
Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner
Nat Commun.
11:5113
PMID: 33037215 -
Zhang et al.
(2018)
DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs.
Invest Ophthalmol Vis Sci.
59(11):4441
PMID: 30193315 -
Chen et al.
(2018)
Altered Baseline and Nicotine-Mediated Behavioral and Cholinergic Profiles in ChAT-Cre Mouse Lines.
J Neurosci.
38:2177
PMID: 29371319 -
Dai et al.
(2018)
Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
Exp Mol Med.
50:148
PMID: 30429454 -
Lee et al.
(2018)
The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD.
J Neuroinflammation.
15:286
PMID: 30309372 -
Cai and Ford
(2018)
DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
Cell Rep.
25:3148
PMID: 30540946 -
Scheggi
(2017)
Fasting biases μ-opioid receptors toward β-arrestin2 dependent signaling in the accumbens shell.
Neuroscience.
352:19
PMID: 28391016 -
Guo
(2017)
DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
Aging Cell.
16(6):1323
PMID: 28975698 -
Kasaharaa et al.
(2016)
The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes
Neuroscience.
340:176
PMID: 27815022 -
Mamaligas et al.
(2016)
Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission
Scientific Reports.
6:37834
PMID: 27886263 -
Beckley et al.
(2016)
The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens DA D1 Receptor Neurons.
J Neurosci.
36:701
PMID: 26791202 -
Fritz et al.
(2016)
Prostaglandin-dependent modulation of DArgic neurotransmission elicits inflammation-induced aversion in mice.
J Clin Invest.
126:695
PMID: 26690700 -
Brzosko et al.
(2015)
Retroactive modulation of spike timing-dependent plasticity by DA.
Elife.
4
PMID: 26516682 -
Tozzi et al.
(2015)
Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
Front Cell Neurosci.
9:192
PMID: 26074768 -
Hao et al.
(2015)
L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating DA D1 receptor/PKA signaling pathway.
Cell Death Dis.
6:e1965
PMID: 26539912 -
Meunier et al.
(2015)
Effect of DArgic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex.
PLoS One.
10:e0120286
PMID: 25775449 -
Kim et al.
(2015)
Spinal DArgic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
J Neurosci.
35:6307
PMID: 25904784 -
Li et al.
(2015)
Incubation of metha. craving is associated with selective increases in expression of Bdnf and trkb, glutamate receptors, and epigenetic enzymes in cue-activated fos-expressing dorsal striatal neurons.
Learn Mem.
35:8232
PMID: 26019338 -
Savalli et al.
(2015)
Regionally selective requirement for D1/D5 DArgic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory.
PLoS One.
22:69
PMID: 25593292 -
Montalbano et al.
(2015)
Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
J Pharmacol Exp Ther.
10:e0140369
PMID: 26460748 -
Conley et al.
(2015)
Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
PLoS One.
352:53
PMID: 25332454 -
Rioult-Pedotti et al.
(2015)
DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
PLoS One.
10:e0124986
PMID: 25938462 -
Pezze et al.
(2015)
DArgic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex.
Behav Neurosci.
232:2669
PMID: 25820982 -
Lee and Chirwa
(2015)
Blocking DArgic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs.
Nat Neurosci.
10:e0135578
PMID: 26275140 -
Marchant and Kaganovsky
(2015)
A critical role of nucleus accumbens DA D1-family receptors in renewal of alcohol seeking after punishment-imposed abstinence.
PLoS One.
129:281
PMID: 25914922 -
Marcott et al.
(2014)
Phasic DA release drives rapid activation of striatal D2-receptors.
Neuron.
84:164
PMID: 25242218 -
Ribeiro et al.
(2014)
Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease.
J Neurosci.
23:2030
PMID: 24282028 -
Zhao et al.
(2014)
Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats.
Br J Pharmacol.
38:256
PMID: 25379005 -
Fuenzalida et al.
(2014)
DA D1 and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells.
J Clin Invest.
171:5650
PMID: 25073922 -
Cilz et al.
(2014)
DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
Cereb Cortex.
24:3195
PMID: 23843440 -
Lee et al.
(2014)
Characterization of the guinea pig animal model and subsequent comparison of the behavioral effects of selective DArgic drugs and metha.
Synapse.
68:221
PMID: 24436154 -
Chen et al.
(2014)
Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: possible interaction with local orexin neurons.
Alcohol Clin Exp Res.
38:777
PMID: 24236888 -
Jia et al.
(2013)
Age-dependent regulation of synaptic connections by DA D2 receptors.
Nat Neurosci.
16:1627
PMID: 24121738 -
Zhang et al.
(2013)
Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians.
Physiol Behav.
112-113:8
PMID: 23415661 -
Corcoran et al.
(2013)
Extinction of remotely acquired fear depends on an inhibitory NR2B/PKA pathway in the retrosplenial cortex.
J Neurosci.
33:19492
PMID: 24336715 -
Lisek et al.
(2012)
Mephedrone ('bath salt') elicits conditioned place preference and DA-sensitive motor activation.
Drug Alcohol Depend.
126:257
PMID: 22652295 -
Huang et al.
(2012)
SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes.
Neuroscience.
7:e49954
PMID: 23185493 -
Prado et al.
(2012)
Stimulation of DA receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity.
Psychopharmacology (Berl).
188:3062
PMID: 22379034 -
Shin et al.
(2011)
Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of DArgic d1 receptor.
Hum Mol Genet.
20:130
PMID: 22110371 -
Krishnan et al.
(2011)
DA-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala.
PLoS One..
6:e25639
PMID: 21980514 -
Li et al.
(2011)
Synergistic activation of DA D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala.
PLoS One.
6:e26065
PMID: 22022509 -
Raghuraman et al.
(2010)
Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of DA D1 receptor signaling.
J Neurochem.
115:1568
PMID: 20969567 -
Krishnan et al.
(2010)
DA receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal.
Eur J Neurosci.
31:1027
PMID: 20377617 -
Xu et al.
(2010)
Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperDArgic mutant.
Exp Neurobiol.
115:1643
PMID: 20969573 -
Deng et al.
(2010)
MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
J Ginseng Res.
13:1128
PMID: 20711186 -
Goffin et al.
(2010)
DA-dependent tuning of striatal inhibitory synaptogenesis.
J Neurosci.
30:2935
PMID: 20181591 -
Schwendt and McGinty
(2010)
Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of DA and glucocorticoid receptors.
J Neurosci.
168:96
PMID: 20298760 -
Nunes et al.
(2010)
Differential effects of selective adenosine antagonists on the effort-related impairments induced by DA D1 and D2 antagonism.
Neuroscience.
170:268
PMID: 20600675 -
Chuhma et al.
(2009)
DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
Neuroscience.
164:1068
PMID: 19729052 -
Xu et al.
(2009)
HyperDArgic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate.
J Immunol.
29:14086
PMID: 19906957 -
Ma et al.
(2009)
Activation of phosphatidylinositol-linked novel D1 DA receptors inhibits high-voltage-activated Ca2+ currents in primary cultured striatal neurons.
J Neurophysiol.
101:2230
PMID: 19225177 -
Costa et al.
(2008)
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
J Neurosci.
28:8040
PMID: 18685029 -
Kash et al.
(2008)
DA enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
J Neurochem.
28:13856
PMID: 19091975 -
Witkovsky et al.
(2007)
Cellular localization and function of DARPP-32 in the rodent retina.
Eur J Neurosci.
25:3233
PMID: 17552992 -
Rao et al.
(2007)
Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.
J Neurosci.
117:4022
PMID: 18060037 -
Clancy et al.
(2007)
Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.
PLoS One.
27:6388
PMID: 17567799 -
Nackley et al.
(2007)
Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.
Pain.
128:199
PMID: 17084978 -
Meredith et al.
(2006)
DA targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.
Proc Natl Acad Sci U S A.
103:13485
PMID: 16938864
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Customer Reviews for SCH 23390 hydrochloride (3)
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Species: HumanCell Line/Tissue: Stem cell - derived neuronsSCH‐23390 was in use as a dopamine receptor antagonist. Being applied at stem cell – derived cultured neurons (10 nM concentration) together with sulpiride, caused an increase of amplitudes of evoked post-synaptic potentials generated by NMDA receptors (see illustration). Preparation of 10 mM water stocks requires sonication.
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Species: RatAssay Type: In VivoAt a dose that did not alter responding during food self-administration (6 micrograms/kg), systemic injections of SCH 23390 blocked responding during cue-induced reinstatement of food seeking tests.
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Species: MouseAssay Type: In VivoOur lab has used SCH23390 to block dopaminergic D1 receptors and to check its effect on locomotion. Mice were injected with this drug and we noticed that SCH23390 decreased the average speed during a 5-minute test.
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