SCH 23390 hydrochloride

Name: SCH 23390 hydrochloride
Brand: Tocris Bioscience
SKU: 0925
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0925

(3)

Citations (128)

COA / SDS

Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker

Key Product Details

Description:	Selective D₁-like antagonist; also 5-HT_2C agonist and K_ir3 channel blocker
Alternative Names:	(R)-(+)-SCH 23390 hydrochloride
Chemical Name:	(R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	324.24

View Full Technical Details for SCH 23390 hydrochloride

Technical Data
Citations / Reviews (3)

Biological Activity for SCH 23390 hydrochloride

SCH 23390 hydrochloride is a potent dopamine receptor antagonist (K_i values are 0.2 nM and 0.3 nM at D₁ and D₅ receptor sub-types, respectively). Also an agonist at 5-HT_2C receptors in vitro (K_i values are 6.3 - 9.3 nM). Blocks quinpirole-induced K_ir3 (GIRK) currents (EC₅₀ = 268 nM) independently of receptors.

Technical Data for SCH 23390 hydrochloride

M. Wt	324.24
Formula	C₁₇H₁₈ClNO.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	125941-87-9
PubChem ID	11957535
InChi Key	OYCAEWMSOPMASE-XFULWGLBSA-N
Smiles	ClC1=C(O)C=C([C@](C3=CC=CC=C3)([H])C2)C(CCN2C)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 23390 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	32.42	100 with gentle warming
	ethanol	16.21	50

Preparing Stock Solutions for SCH 23390 hydrochloride

The following data is based on the product molecular weight 324.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.42 mL	30.84 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for SCH 23390 hydrochloride

References are publications that support the biological activity of the product.

Kuzhikandathil and Oxford Classic D₁ DA receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol.Pharmacol. 2002 PMID: 12065762
Briggs Activation of the 5-HT_1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 1991 PMID: 1687364
Millan The "selective" DA D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist against cloned human serotonin_2C receptors. Psychopharmacology 2001 PMID: 11465634
Bourne SCH 23390: The first selective DA D₁-like receptor antagonist. CNS Drug Rev. 2001 PMID: 11830757