SCH 23390 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0925
Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
Key Product Details
Description
Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
Alternative Names
(R)-(+)-SCH 23390 hydrochloride
Product Description
SCH 23390 hydrochloride is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT2C receptors in vitro (Ki values are 6.3 - 9.3 nM). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.Product Specifications
Molecular Weight
324.24
Formula
C17H18ClNO.HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
(R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
CAS Number
125941-87-9
PubChem ID
11957535
InChI Key
OYCAEWMSOPMASE-XFULWGLBSA-N
SMILES
ClC1=C(O)C=C([C@](C3=CC=CC=C3)([H])C2)C(CCN2C)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 32.42 | 100 with gentle warming | |
| Ethanol | 16.21 | 50 |
Preparing Stock Solutions
for SCH 23390 hydrochloride
The following data is based on the product molecular weight 324.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.08 mL | 15.42 mL | 30.84 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kuzhikandathil and Oxford Classic D1 DA receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol.Pharmacol. 2002 PMID: 12065762
- Briggs Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 1991 PMID: 1687364
- Millan The "selective" DA D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist against cloned human serotonin2C receptors. Psychopharmacology 2001 PMID: 11465634
- Bourne SCH 23390: The first selective DA D1-like receptor antagonist. CNS Drug Rev. 2001 PMID: 11830757
Product Specific Notices for SCH 23390 hydrochloride
For research use only
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