SB 243213 dihydrochloride

Name: SB 243213 dihydrochloride
Brand: Tocris Bioscience
SKU: 3527

Tocris Bioscience, part of Bio-Techne | Catalog # 3527

Citations (5)

COA / SDS

Selective 5-HT2C inverse agonist

Discontinued Product

3527 has been discontinued. View all 5-HT2C Receptor Inverse Agonists products.

Key Product Details

Description:	Selective 5-HT_2C inverse agonist
Chemical Name:	2,3-Dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-Indole-1-carboxamide dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	501.33

View Full Technical Details for SB 243213 dihydrochloride

Technical Data
Citations

Biological Activity for SB 243213 dihydrochloride

SB 243213 dihydrochloride is a selective 5-HT_2C inverse agonist (pK_b = 9.8). Displays selectivity over other 5-HT₂ subtypes (pK_i values are 6.8, 7.0 and 9.0 for 5-HT_2A, 5-HT_2B and 5-HT_2C respectively); also exhibits >100-fold selectivity over 50 other receptors, ion channels and enzymes. Displays anxiolytic activity in rat models.

Technical Data for SB 243213 dihydrochloride

M. Wt	501.33
Formula	C₂₂H₁₉F₃N₄O₂.2HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1780372-25-9
PubChem ID	90488853
InChi Key	UKMTYUXWLKQDNT-UHFFFAOYSA-N
Smiles	O=C(N3C(C=C(C(F)(F)F)C(C)=C4)=C4CC3)NC(C=C2)=CN=C2OC1=CC=CN=C1C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SB 243213 dihydrochloride

References are publications that support the biological activity of the product.

Wood SB-243213; a selective 5-HT_2C receptor inverse agonist with improved anxiolytic profile: lack of tolderance and withdrawal anxiety. Neuropharmacology 2001 PMID: 11489455
Berg Differential effects of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxyl]-5-pyridyl]carbamoyl]-6-trifluoromethylindone (SB 243213) on 5-hydroxytryptamine_2C receptor-mediated responses. J.Pharmacol.Exp.Ther. 2006 PMID: 16807362
Bromidge Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic a J.Med.Chem. 2000 PMID: 10737744

SB 243213 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3527

Key Product Details

Biological Activity for SB 243213 dihydrochloride

Technical Data for SB 243213 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for SB 243213 dihydrochloride

Product Documents for SB 243213 dihydrochloride

COA

Certificate of Analysis

SDS

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