SB 228357

Name: SB 228357
Brand: Tocris Bioscience
SKU: 1375

Tocris Bioscience, part of Bio-Techne | Catalog # 1375

COA / SDS

5-HT2C/2B antagonist/inverse agonist

Discontinued Product

1375 has been discontinued. View all 5-HT2C Receptor Antagonists products.

Key Product Details

Description:	5-HT_2C/2B antagonist/inverse agonist
Chemical Name:	N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	431.39

View Full Technical Details for SB 228357

Technical Data
Citations

Biological Activity for SB 228357

SB 228357 is a 5-HT_2C/2B receptor antagonist (pK_i values are 7.0, 8.1 and 9.1 at 5-HT_2A, _2B and _2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT_2C receptor function. Orally active in vivo.

Licensing Information

Sold under license

Technical Data for SB 228357

M. Wt	431.39
Formula	C₂₂H₁₇F₄N₃O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	181629-93-6
PubChem ID	443390
InChi Key	RRJLJKRFFRZRAF-UHFFFAOYSA-N
Smiles	COC1=C(C=C2N(CCC2=C1)C(=O)NC1=CC(F)=CC(=C1)C1=CC=CN=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SB 228357

References are publications that support the biological activity of the product.

Reavill Attenuation of haloperidol-induced catalepsy by a 5-HT_2C receptor antagonist. Br.J.Pharmacol. 1999 PMID: 10188965
Bromidge Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic ag J.Med.Chem. 2000 PMID: 10737744