Salermide

Name: Salermide
Brand: Tocris Bioscience
SKU: 4127

Tocris Bioscience, part of Bio-Techne | Catalog # 4127

COA / SDS

SIRT1 and SIRT2 inhibitor

Discontinued Product

4127 has been discontinued. View all Class III Histone Deacetylases Inhibitors products.

Key Product Details

Description:	SIRT1 and SIRT2 inhibitor
Chemical Name:	N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	394.47

View Full Technical Details for Salermide

Technical Data
Citations

Biological Activity for Salermide

Salermide is a SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours.

Technical Data for Salermide

M. Wt	394.47
Formula	C₂₆H₂₂N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1105698-15-4
PubChem ID	53393948
InChi Key	UADRPWLRVLBVBC-UHFFFAOYSA-N
Smiles	O=C(C(C)C4=CC=CC=C4)NC1=CC=CC(/N=C/C3=C(O)C=CC2=CC=CC=C23)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Salermide

References are publications that support the biological activity of the product.

Lara Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene 2009 PMID: 19060927
Pasco Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues. J.Med.Chem. 2010 PMID: 20041717
Mai Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 2005 PMID: 16302818

Salermide

Tocris Bioscience, part of Bio-Techne | Catalog # 4127

Key Product Details

Biological Activity for Salermide

Technical Data for Salermide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Salermide

Product Documents for Salermide

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected