(S)-Equol

Name: ( S )-Equol
Brand: Tocris Bioscience
SKU: 6158

Tocris Bioscience, part of Bio-Techne | Catalog # 6158

COA / SDS

Potent estrogen receptor β (ERβ) agonist; dihydrotestosterone antagonist

Discontinued Product

6158 has been discontinued. View all Estrogen and Related Receptor Agonists products.

Key Product Details

Description:	Potent estrogen receptor β (ERβ) agonist; dihydrotestosterone antagonist
Chemical Name:	(3S)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol
Purity:	≥98% (HPLC)
Molecular Weight:	242.27

View Full Technical Details for (S)-Equol

Technical Data
Citations

Biological Activity for (S)-Equol

(S)-Equol is a potent estrogen receptor β (ERβ) agonist (EC₅₀ = 65 nM). Exhibits 13-fold selectivity for ERβ over ERα. Atheroprotective. Protects against t-BHP induced apoptosis and attenuates ER stress in HUVECs. Activates Nrf2 signaling in vitro and in vivo. Inhibits tumor growth. Also dihydrotestosterone antagonist in vivo.

Technical Data for (S)-Equol

M. Wt	242.27
Formula	C₁₅H₁₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	531-95-3
PubChem ID	91469
InChi Key	ADFCQWZHKCXPAJ-GFCCVEGCSA-N
Smiles	OC1=CC=C([C@H]2COC3=CC(O)=CC=C3C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for (S)-Equol

References are publications that support the biological activity of the product.

Setchell S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am.J.Clin.Nutr. 2005 PMID: 15883431
Zhang Equol attenuates atherosclerosis in apolipoprotein e-deficient mice by inhibiting endoplasmic reticulum stress via activation of Nrf2 in endothelial cells. PLoS One. 2016 PMID: 27907038
Muthyala Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg.Med.Chem. 2004 PMID: 15018930
Yuan Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer. Oncotarget. 2016 PMID: 27323858

(S)-Equol

Tocris Bioscience, part of Bio-Techne | Catalog # 6158

Key Product Details

Biological Activity for (S)-Equol

Technical Data for (S)-Equol

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for (S)-Equol

Product Documents for (S)-Equol

COA

Certificate of Analysis

SDS

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