RS 79948 hydrochloride

Name: RS 79948 hydrochloride
Brand: tocris
SKU: 0987

Catalog # 0987

Citations (4)

Datasheet / COA / SDS

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$35 to United States

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Key Product Details

Description:	Potent and selective α₂ antagonist
Chemical Name:	(8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride
Purity:	≥99% (HPLC)

View Full Technical Details for RS 79948 hydrochloride

Biological Activity

α₂-adrenoreceptor antagonist (K_d values are; 0.18, 0.19 and 0.42 nM for α_2B α_2C and α_2A, respectively in rat).

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt	400.96
Formula	C₁₉H₂₈N₂O₃S.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	186002-54-0
PubChem ID	9908991
InChi Key	DZTZUOBWDBPPJQ-BQBHMPFISA-N
Smiles	[H][C@]12C4=C(C=C(OC)C=C4)CCN1C[C@]3([H])[C@](N(S(=O)(CC)=O)CCC3)([H])C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		25

Preparing Stock Solutions

The following data is based on the product molecular weight 400.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.98 mL	49.88 mL	99.76 mL
1.25 mM	2.00 mL	9.98 mL	19.95 mL
2.5 mM	1.00 mL	4.99 mL	9.98 mL
12.5 mM	0.20 mL	1.00 mL	2.00 mL

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References

References are publications that support the biological activity of the product.

Clark (8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(ethylsulphonyl)-6H-isoquino[2,1-g][1,6]-naphthyridine, a potent and highly selective α₂-adrenoceptor antagonist. J. Med. Chem. 1989 PMID: 2570150
Hume Evaluation in rat of RS-79948-197 as a potential PET ligand for central α₂-adrenoceptors. Eur.J.Pharmacol. 1996 PMID: 8982721
Uhlen [³H]RS79948-197 binding to rat, guinea pig and pig α_2A-, α_2B and α_2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 1998 PMID: 9551719

Showing 1-4 of 4 citations

Citations (4)

Citations are publications that use Bio-techne products. Selected citations for RS 79948 hydrochloride include:

Chen et al. (2019) Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α_2C Adrenergic Receptor. Cell Reports. 29:2936
PMID: 31801061
Qu et al. (2019) Structural Basis of the Diversity of Adrenergic Receptors. Cell Reports. 29:2929
PMID: 31801060
Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology. 118:79
PMID: 28300552
Zacharia et al. (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One. 8:e65969
PMID: 23776582

RS 79948 hydrochloride

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References

Citations (4)

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