RS 79948 hydrochloride

Name: RS 79948 hydrochloride
Brand: Tocris Bioscience
SKU: 0987

Tocris Bioscience, part of Bio-Techne | Catalog # 0987

Citations (16)

COA / SDS

Potent and selective α2 antagonist

Key Product Details

Description:	Potent and selective α₂ antagonist
Chemical Name:	(8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	400.96

View Full Technical Details for RS 79948 hydrochloride

Technical Data
Citations

Biological Activity for RS 79948 hydrochloride

RS 79948 hydrochloride is a α₂-adrenoreceptor antagonist (K_d values are; 0.18, 0.19 and 0.42 nM for α_2B α_2C and α_2A, respectively in rat).

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for RS 79948 hydrochloride

M. Wt	400.96
Formula	C₁₉H₂₈N₂O₃S.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	186002-54-0
PubChem ID	9908991
InChi Key	DZTZUOBWDBPPJQ-BQBHMPFISA-N
Smiles	[H][C@]12C4=C(C=C(OC)C=C4)CCN1C[C@]3([H])[C@](N(S(=O)(CC)=O)CCC3)([H])C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RS 79948 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		25

Preparing Stock Solutions for RS 79948 hydrochloride

The following data is based on the product molecular weight 400.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.98 mL	49.88 mL	99.76 mL
1.25 mM	2.00 mL	9.98 mL	19.95 mL
2.5 mM	1.00 mL	4.99 mL	9.98 mL
12.5 mM	0.20 mL	1.00 mL	2.00 mL

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References for RS 79948 hydrochloride

References are publications that support the biological activity of the product.

Hume Evaluation in rat of RS-79948-197 as a potential PET ligand for central α₂-adrenoceptors. Eur.J.Pharmacol. 1996 PMID: 8982721
Uhlen [³H]RS79948-197 binding to rat, guinea pig and pig α_2A-, α_2B and α_2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 1998 PMID: 9551719
Clark (8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(ethylsulphonyl)-6H-isoquino[2,1-g][1,6]-naphthyridine, a potent and highly selective α₂-adrenoceptor antagonist. J. Med. Chem. 1989 PMID: 2570150