RS 17053 hydrochloride

Name: RS 17053 hydrochloride
Brand: tocris
SKU: 0985

Catalog # 0985

Datasheet / COA / SDS

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Bio-Techne Corporation

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$35 to United States

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Key Product Details

Description:	α_1A antagonist
Chemical Name:	(N-[2-(2-Cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine) hydrochloride
Molecular Weight:	449.42

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Biological Activity

α_1A-adrenoceptor antagonist, with very high affinity for α_1A receptors (pK_i and pA₂ estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α_1B and α_1D subtypes (pK_i and pA₂ estimates 7.7 - 7.8).

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt	449.42
Formula	C₂₄H₂₉N₂O₂Cl.HCl
Storage	Store at RT
CAS Number	169505-93-5
PubChem ID	9824953
InChi Key	QFOPFGRPNPCPBX-UHFFFAOYSA-N
Smiles	Cl.CC(C)(CC1=CNC2=CC=C(Cl)C=C12)NCCOC1=C(OCC2CC2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	4.49	10
	DMSO	22.47	50

Preparing Stock Solutions

The following data is based on the product molecular weight 449.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.45 mL	22.25 mL	44.50 mL
2.5 mM	0.89 mL	4.45 mL	8.90 mL
5 mM	0.45 mL	2.23 mL	4.45 mL
25 mM	0.09 mL	0.45 mL	0.89 mL

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References

References are publications that support the biological activity of the product.

Ford RS 17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine hydrochloride, a selective α1A-adrenoceptor antagonist, displays low affinity for functional α1-adrenoceptors in huma Mol.Pharmacol. 1996 PMID: 8632751
Marshall Different subtypes of α_1A-adrenoceptor mediating contraction of rat epididymal vas deferens, rat hepatic portal vein and human prostate distinguished by the antagonist RS 17053. Br.J.Pharmacol. 1996 PMID: 8886428
Ford Do α_1A (α_1C)-adrenoceptors (AR) mediate prostatic smooth muscle contraction in man? Studies with a novel, selective α_1A-AR antagonist, RS 17053. Br.J.Pharmacol.