Roxindole hydrochloride

Name: Roxindole hydrochloride
Brand: Tocris Bioscience
SKU: 1559

Tocris Bioscience a Bio-Techne Brand

Catalog # 1559

COA / SDS

Discontinued Product

1559 has been discontinued. View all Non-selective Dopamine Receptor Agonists products.

Key Product Details

Description:	Dopamine D₂ autoreceptor agonist. Also has affinity for D₃, D₄, 5-HT_1A receptors and the 5-HT transporter
Alternative Names:	EMD 49980
Chemical Name:	3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	382.93

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Biological Activity for Roxindole hydrochloride

Roxindole hydrochloride is a dopamine D₂ autoreceptor agonist, with affinity for D₃, D₄ and 5-HT₁ receptors (pK_i values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D₂, D₃, D₄, 5-HT_1A, 5-HT_1B and 5-HT_1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo.

Technical Data for Roxindole hydrochloride

M. Wt	382.93
Formula	C₂₃H₂₆N₂O.HCl
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	108050-82-4
PubChem ID	9886286
InChi Key	ZCEPVNSWLLJECX-UHFFFAOYSA-N
Smiles	OC(C=C4)=CC1=C4NC=C1CCCCN2CCC(C3=CC=CC=C3)=CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Roxindole hydrochloride

References are publications that support the biological activity of the product.

Newman-Tancredi Actions of roxindole at recombinant human DA D₂, D₃ and D₄ and serotonin 5-HT_1A, 5-HT_1B and 5-HT_1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 1999 PMID: 10431754
Bartoszyk Roxindole: psychopharmacological profile of a DA D₂ autoreceptor agonist. J.Pharmacol.Exp.Ther. 1996 PMID: 8558454
Seyfried Biochemical and functional studies on EMD 49980: a potent, selectively presynaptic D-2 DA agonist with actions on serotonin systems. Eur.J.Pharmacol. 1989 PMID: 2565817

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Roxindole hydrochloride

Tocris Bioscience a Bio-Techne Brand

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References for Roxindole hydrochloride

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