RETRA hydrochloride

Name: RETRA hydrochloride
Brand: Tocris Bioscience
SKU: 3214

Tocris Bioscience a Bio-Techne Brand

Catalog # 3214

COA / SDS

Discontinued Product

3214 has been discontinued. View all Additional p53-related Compounds products.

Key Product Details

Description:	Antitumor agent; suppresses mutant p53-bearing cancer cells
Chemical Name:	2-[(4,5-Dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)ethanone hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	305.8

View Full Technical Details for RETRA hydrochloride

Biological Activity for RETRA hydrochloride

RETRA hydrochloride is an antitumor agent. Inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC₅₀ = 4 μM). Transcriptionally activates expression of p53-responsive genes and induces activation of effector caspases 3 and 7.

Technical Data for RETRA hydrochloride

M. Wt	305.8
Formula	C₁₁N₁₁NO₃S₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1173023-52-3
PubChem ID	46861546
InChi Key	ZZAVDVMJZKDBIB-UHFFFAOYSA-N
Smiles	OC1=CC(C(CSC2=NCCS2)=O)=CC=C1O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RETRA hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.58	100

Preparing Stock Solutions for RETRA hydrochloride

The following data is based on the product molecular weight 305.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.27 mL	16.35 mL	32.70 mL
5 mM	0.65 mL	3.27 mL	6.54 mL
10 mM	0.33 mL	1.64 mL	3.27 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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References for RETRA hydrochloride

References are publications that support the biological activity of the product.

Kravchenko Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc.Natl.Acad.Sci.USA

Citations for RETRA hydrochloride

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