RCM 1

Name: RCM 1
Brand: Tocris Bioscience
SKU: 6845

Tocris Bioscience, part of Bio-Techne | Catalog # 6845

Citations (1)

COA / SDS

FOXM1 inhibitor

Discontinued Product

6845 has been discontinued. View all FoxM1 products.

Key Product Details

Description:	FOXM1 inhibitor
Chemical Name:	2-[[2-Oxo-2-(2-thienyl)ethyl]thio]-4,6-di-2-thienyl-3-pyridinecarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	424.58

View Full Technical Details for RCM 1

Technical Data
Citations

Biological Activity for RCM 1

RCM 1 is a forkhead box M1 (FOXM1) transcription factor inhibitor (IC₅₀ = 0.72 μM). Inhibits expression of FOXM1 target genes. Induces FOXM1 protein degradation in vitro. Reduces airway resistance, increases lung compliance and decreases proinflammatory cytokine production in allergen-exposed mice.

Technical Data for RCM 1

M. Wt	424.58
Formula	C₂₀H₁₂N₂OS₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	339163-65-4
PubChem ID	4273985
InChi Key	DCCYTKKDAZEVLY-UHFFFAOYSA-N
Smiles	O=C(C1=CC=CS1)CSC2=C(C(C3=CC=CS3)=CC(C4=CC=CS4)=N2)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for RCM 1

References are publications that support the biological activity of the product.

Sun The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci.Signal. 2017 PMID: 28420758

RCM 1

Tocris Bioscience, part of Bio-Techne | Catalog # 6845

Key Product Details

Biological Activity for RCM 1

Technical Data for RCM 1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for RCM 1

Product Documents for RCM 1

COA

Certificate of Analysis

SDS

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