R 1485 dihydrochloride

Name: R 1485 dihydrochloride
Brand: Tocris Bioscience
SKU: 4964

Tocris Bioscience, part of Bio-Techne | Catalog # 4964

COA / SDS

Selective and high affinity 5-HT6 antagonist

Discontinued Product

4964 has been discontinued. View all 5-HT6 Receptor Antagonists products.

Key Product Details

Description:	Selective and high affinity 5-HT₆ antagonist
Chemical Name:	4-[(2-Fluorophenyl)sulfonyl]-3,4-dihydro-8-(1-piperazinyl)-2H-1,4-benzoxazine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	450.35

View Full Technical Details for R 1485 dihydrochloride

Technical Data
Citations

Biological Activity for R 1485 dihydrochloride

R 1485 dihydrochloride is a selective and high affinity 5-HT₆ antagonist (pK_i = 8.9); displays low hERG inhibition. Exhibits >100 fold selectivity against a panel of 50 targets including other 5-HT receptor subtypes. Brain penetrant.

Technical Data for R 1485 dihydrochloride

M. Wt	450.35
Formula	C₁₈H₂₀FN₃O₃S.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	90488993
InChi Key	SNXURKRGPYXWRN-UHFFFAOYSA-N
Smiles	FC(C=CC=C4)=C4S(N2CCOC1=C(N3CCNCC3)C=CC=C12)(=O)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for R 1485 dihydrochloride

References are publications that support the biological activity of the product.

Liu 5-HT₆ antagonists as potential treatment for cognitive dysfunction. Drug Des.Rev.
Zhao 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT₆ receptor antagonists. Bioorg.Med.Chem.Lett. 2007 PMID: 17485206

R 1485 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4964

Key Product Details

Biological Activity for R 1485 dihydrochloride

Technical Data for R 1485 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for R 1485 dihydrochloride

Product Documents for R 1485 dihydrochloride

COA

Certificate of Analysis

SDS

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