Pseudo RACK1

Name: Pseudo RACK1
Brand: Tocris Bioscience
SKU: 1790

Tocris Bioscience a Bio-Techne Brand

Catalog # 1790

COA / SDS

Discontinued Product

1790 has been discontinued. View all Protein Kinase C Activators products.

Key Product Details

Description:	Protein kinase C activator peptide (attached to cell permeable vector)
Molecular Weight:	3198.81

View Full Technical Details for Pseudo RACK1

Biological Activity for Pseudo RACK1

Pseudo RACK1 is an activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the activator peptide. Once inside the cell, the disulfide bonds are subjected to reduction in the cytoplasm leading to release of the activator peptide.

Technical Data for Pseudo RACK1

M. Wt	3198.81
Formula	C₁₄₄H₂₂₅N₄₃O₃₄S₃
Single Letter Sequence	KKWKMRRNQFWIKIQRC CSVEIWD* (Modifcations: Disulfide bridge between 17 -1*)
Storage	Store at -20°C
PubChem ID	90488710
InChi Key	LTAVZZKCZYNJEE-PMCSTDROSA-N
Smiles	[H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pseudo RACK1

Solubility

Soluble Soluble to 2 mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Pseudo RACK1

References are publications that support the biological activity of the product.

Ron and Mochly-Rosen An autoregulatory region in protein kinase C: the pseudoanchoring site. Proc.Natl.Acad.Sci.U.S.A. 1995 PMID: 7831317
Theodore Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 1995 PMID: 7472470
Derossi The third helix of the antennapedia homeodomain translocates through biological membranes. J.Biol.Chem. 1994 PMID: 8144628

Citations for Pseudo RACK1

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.