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PRE-084 hydrochloride

Sigma1 Receptor Agonists Small Molecule

Key Product Details

Description: Highly selective σ1 agonist
Chemical Name: 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride
Purity: ≥99% (HPLC)
Molecular Weight: 353.89

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Citations (19)

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Customer Reviews (2)

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  • Consistent Reproducible Results
    Name: Zeinab Motawe
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human Umbilical Vein Endothelial Cells (HUVECs)
    I used it to test the effects of sigma-1 receptor activation on glycolysis in endothelial cells using Agilent seahorse XFp instrument (Agilent Technologies, Santa Clara, CA, USA)
  • Worked great for all assays used
    Name: Zeinab Motawe
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human Dermal Microvascular Endothelial Cells (HDMEC)
    I used it to test its effect on trans-endothelial electrical resistance (TER) of human dermal microvascular endothelial cells (HDMEC) which gives an idea about endothelial barrier using electrical cell substrate impedance sensing (ECIS). HDMEC (Lifeline cell technologies Frederick, MD, USA) were seeded on ECIS microarrays (applied physics, Troy, NY, USA), grown till confluence. Then cells were serum starved for 1 hour and different concentrations of PRE-084 were added. TER was recorded over time. The graph showed TER differences at 8 hours. n=4/group. Analysis was done by One-Way ANOVA followed by Dunnett's multiple comparison test. *p<0.05. **p<0.005, ***p<0.0005
    I diluted it with water and made stock solutions of 10 mM. Stocks were kept in -20.
    Worked great for all assays used Serum 0589

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