PRE-084 hydrochloride

Citations are publications that use Bio-Techne products. Selected citations for PRE-084 hydrochloride include:

• Corté s-Montero et al. (2019) Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels. Front Pharmacol. 10:634
  PMID: 31249525
• Abraham et al. (2019) The sigma-1 receptor behaves as an atypical auxiliary subunit to modulate the functional characteristics of Kv1.2 channels expressed in HEK293 cells. Physiol Rep. 7:e14147
  PMID: 31222975
• Brailoiu et al. (2019) Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca²⁺ Signals through Sigma-1 Receptors. Cell Rep. 26:330
  PMID: 30625315
• Rodríguez-Muñoz et al. (2018) Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain. 11:51
  PMID: 30223868
• Sánchez-Blázquez et al. (2018) The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9. Mol Neurobiol. 55:4940
  PMID: 28779350
• Atzmon et al. (2018) Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy. Front Mol Neurosci. 11:336
  PMID: 30279648
• Sánchez-Blázquez et al. (2018) Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice. Int J Neuropsychopharmacol. 21:938
  PMID: 29860313
• Rodríguez-Muñoz et al. (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Br J Pharmacol. 6:35458
  PMID: 26461475
• Malik et al. (2015) The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. Int J Neuropsychopharmacol. 172:2519
  PMID: 25573298
• Navarro et al. (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Br J Ophthalmol. 35:6639
  PMID: 25926444
• Szabo et al. (2014) Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. PLoS One. 9:e106533
  PMID: 25171370
• Sánchez-Blázquez et al. (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. J Neurosci. 17:1943
  PMID: 24485144
• Moreno et al. (2014) Cocaine disrupts histamine H3 receptor modulation of DA D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci. 34:3545
  PMID: 24599455
• Iñiguez et al. (2013) Inhibitory effects of sigma-2 receptor agonists on T lymphocyte activation. Front Pharmacol. 4:23
  PMID: 23494519
• Hiranita et al. (2013) Stimulants as specific inducers of DA-independent σ agonist self-administration in rats. ScientificWorldJournal. 347:42633
  PMID: 23908387
• Kim et al. (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun. 426:177
  PMID: 22925888
• Roh et al. (2011) Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation. Br J Pharmacol. 163:1707
  PMID: 21391983
• Cantarella et al. (2007) Protective effects of the σ agonist Pre-084 in the rat retina. J Pharmacol Exp Ther. 91:1382
  PMID: 17522150
• Brown et al. (2004) Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Br J Pharmacol. 141:233
  PMID: 14691051

There are no citations that match your criteria.

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• Consistent Reproducible Results

  Name: Zeinab Motawe
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: Human Umbilical Vein Endothelial Cells (HUVECs)
  I used it to test the effects of sigma-1 receptor activation on glycolysis in endothelial cells using Agilent seahorse XFp instrument (Agilent Technologies, Santa Clara, CA, USA)
  PMID: 32279379 Reference

• Worked great for all assays used

  Name: Zeinab Motawe
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: Human Dermal Microvascular Endothelial Cells (HDMEC)
  I used it to test its effect on trans-endothelial electrical resistance (TER) of human dermal microvascular endothelial cells (HDMEC) which gives an idea about endothelial barrier using electrical cell substrate impedance sensing (ECIS). HDMEC (Lifeline cell technologies Frederick, MD, USA) were seeded on ECIS microarrays (applied physics, Troy, NY, USA), grown till confluence. Then cells were serum starved for 1 hour and different concentrations of PRE-084 were added. TER was recorded over time. The graph showed TER differences at 8 hours. n=4/group. Analysis was done by One-Way ANOVA followed by Dunnett's multiple comparison test. *p<0.05. **p<0.005, ***p<0.0005
  I diluted it with water and made stock solutions of 10 mM. Stocks were kept in -20.
  PMID: 32279379
  

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