PRE-084 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0589
Highly selective σ1 agonist
Product Description
PRE-084 hydrochloride is a high affinity, selective σ1 agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively). Selective over PCP receptors (IC50 > 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effects in vivo. Also exhibits protective effects in PC6.3 cells expressing mutant huntingtin by activating NF-κB signaling.Product Specifications
Molecular Weight
353.89
Formula
C19H27NO3.HCl
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride
CAS Number
138847-85-5
PubChem ID
11314197
InChI Key
QUJWFJNHTBKCLU-UHFFFAOYSA-N
SMILES
Cl.O=C(OCCN1CCOCC1)C1(CCCCC1)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25 | ||
| DMSO | 26.54 | 75 |
Preparing Stock Solutions
for PRE-084 hydrochloride
The following data is based on the product molecular weight 353.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 3.77 mL | 18.84 mL | 37.68 mL |
| 3.75 mM | 0.75 mL | 3.77 mL | 7.54 mL |
| 7.5 mM | 0.38 mL | 1.88 mL | 3.77 mL |
| 37.5 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hyrskyluoto Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway. Cell Death Dis. 2013 PMID: 23703391
- Maurice The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (σ) receptor ligands involves both σ1 and σ2 sites. Br.J.Pharmacol. 1999 PMID: 10385231
- Su Sigma compounds derived from phencyclidine. Identification of PRE-084, a new selective sigma ligand. J.Pharmacol.Exp.Ther. 1991 PMID: 1658302
- Brown Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Br.J.Pharmacol. 2004 PMID: 14691051
Product Specific Notices for PRE-084 hydrochloride
For research use only
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