PKC ζ pseudosubstrate

Name: PKC ζ pseudosubstrate
Brand: Tocris Bioscience
SKU: 1791

Tocris Bioscience, part of Bio-Techne | Catalog # 1791

Citations (35)

COA / SDS

PKC ζ inhibitor peptide (attached to cell-permeable vector)

Discontinued Product

1791 has been discontinued. View all Protein Kinase C Inhibitors products.

Key Product Details

Description:	PKC ζ inhibitor peptide (attached to cell-permeable vector)
Alternative Names:	Protein kinase C zeta pseudosubstrate
Molecular Weight:	4673.59

View Full Technical Details for PKC ζ pseudosubstrate

Technical Data
Citations

Biological Activity for PKC ζ pseudosubstrate

PKC ζ pseudosubstrate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.

Technical Data for PKC ζ pseudosubstrate

M. Wt	4673.59
Formula	C₂₀₈H₃₃₆N₇₄O₄₄S₃
Single Letter Sequence	CRQIKIWFQNRRMKWKK CSIYRRGARRWRKLYRAN* (Modifications: Disulfide bridge between 1 -1*)
Storage	Store at -20°C
PubChem ID	90488711
InChi Key	BQLVLLVGFUIFFK-OXSGATHOSA-N
Smiles	[H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PKC ζ pseudosubstrate

References are publications that support the biological activity of the product.

Lim A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity. Life Sci. 2008 PMID: 18289606
Theodore Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 1995 PMID: 7472470
Laudanna Evidence of ζ protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J.Biol.Chem 1998 PMID: 9804792

PKC ζ pseudosubstrate

Tocris Bioscience, part of Bio-Techne | Catalog # 1791

Key Product Details

Biological Activity for PKC ζ pseudosubstrate

Technical Data for PKC ζ pseudosubstrate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PKC ζ pseudosubstrate

Product Documents for PKC ζ pseudosubstrate

COA

Certificate of Analysis

SDS

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