PKA inhibitor fragment (6-22) amide

Name: PKA inhibitor fragment (6-22) amide
Brand: Tocris Bioscience
SKU: 1904
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1904

(1)

Citations (23)

COA / SDS

Potent protein kinase A inhibitor

Key Product Details

Description:	Potent protein kinase A inhibitor
Alternative Names:	Protein kinase inhibitor-(6-22)-amide,PKI-(6-22)-amide
Purity:	≥95% (HPLC)
Molecular Weight:	1868.08

View Full Technical Details for PKA inhibitor fragment (6-22) amide

Technical Data
Citations / Reviews (1)

Biological Activity for PKA inhibitor fragment (6-22) amide

PKA inhibitor fragment (6-22) amide is a potent inhibitor of cAMP-dependent protein kinase (PKA) (K_i = 2.5 nM); derived from the active portion of the heat-stable PKA inhibitor protein PKI.

Technical Data for PKA inhibitor fragment (6-22) amide

M. Wt	1868.08
Formula	C₈₀H₁₃₀N₂₈O₂₄
Single Letter Sequence	TYADFIASGRTGRRNAI (Modifications: Ile-17 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	121932-06-7
PubChem ID	16155227
InChi Key	VAKHFAFLRUNHLQ-PEBJKXEYSA-N
Smiles	[H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PKA inhibitor fragment (6-22) amide

Solubility

Soluble to 1mg/ml in water

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References for PKA inhibitor fragment (6-22) amide

References are publications that support the biological activity of the product.

Glass Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. J.Biol.Chem. 1989 PMID: 2760075
Otmakhova Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses. J.Neurosci. 2000 PMID: 10844013
Glass Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J.Biol.Chem. 1989 PMID: 2722799