Pifithrin-μ

Name: Pifithrin- μ
Brand: Tocris Bioscience
SKU: 2653
Rating: 5 (1 reviews)

Catalog # 2653 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (6)

COA / SDS

Inhibitor of p53-mitochondrial binding

Key Product Details

Description:	Inhibitor of p53-mitochondrial binding
Alternative Names:	NSC 303580
Chemical Name:	2-Phenylethynesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	181.21

View Full Technical Details for Pifithrin-μ

Technical Data
Citations (6) / Reviews (1)

Biological Activity for Pifithrin-μ

Pifithrin-μ inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Pifithrin-μ reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.

Technical Data for Pifithrin-μ

M. Wt	181.21
Formula	C₈H₇NO₂S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	64984-31-2
PubChem ID	327653
InChi Key	ZZUZYEMRHCMVTB-UHFFFAOYSA-N
Smiles	NS(=O)(=O)C#CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pifithrin-μ

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	13.12	100
	ethanol	13.12	100

Preparing Stock Solutions for Pifithrin-μ

The following data is based on the product molecular weight 181.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.52 mL	27.59 mL	55.18 mL
5 mM	1.10 mL	5.52 mL	11.04 mL
10 mM	0.55 mL	2.76 mL	5.52 mL
50 mM	0.11 mL	0.55 mL	1.10 mL

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References for Pifithrin-μ

References are publications that support the biological activity of the product.

Leu A small molecule inhibitor of inducible heat shock protein 70 (HSP70). Mol.Cell 2009 PMID: 19818706
Kawamura Linking the p53 tumor suppressor pathway to somatic cell reprogramming. Nature 2009 PMID: 19668186
Steele 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. Blood 2009 PMID: 19515722
Strom Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat.Chem.Biol. 2006 PMID: 16862141

Citations for Pifithrin-μ (6)

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Citations are publications that use Bio-Techne products. Selected citations for Pifithrin-μ include:

Nemade et al. (2018) Cell death mechanisms of the anti-cancer drug EPEG on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 92:1507
PMID: 29397400
Li et al. (2018) Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Development. 145
PMID: 30545932
Blatzer et al. (2015) Blocking Hsp70 Enhances the Efficiency of amphote. B Treatment against Resistant Aspergillus terreus Strains. Antimicrob Agents Chemother. 59:3778
PMID: 25870060
Xia et al. (2014) EZH2 silencing with RNA interference induces G2/M arrest in human lung cancer cells in vitro. Biomed Res Int. 2014:348728
PMID: 24745014
Wang et al. (2013) Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. PLoS One. 2013:857929
PMID: 23762164
Kojima et al. (2010) The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther. 9:2545
PMID: 20736344

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Pifithrin-μ

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

Cell Line/Tissue: neural cell

Pifithrin-µ were dissolved in DMSO and used at a final concentration of 50 µM for pifithrin-µ according to previous studies in which 10-50 µM pifithrin-µ were employed.

PMID: 30545932

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Product Documents for Pifithrin-μ

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

Pifithrin-μ

Catalog # 2653 | Tocris Bioscience a Bio-Techne Brand

Key Product Details

Biological Activity for Pifithrin-μ

Technical Data for Pifithrin-μ

Solubility for Pifithrin-μ

Preparing Stock Solutions for Pifithrin-μ

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Pifithrin-μ

Citations for Pifithrin-μ (6)

Customer Reviews for Pifithrin-μ (1)

Customer Images

Pifithrin-μ

Product Documents for Pifithrin-μ

COA

Certificate of Analysis

SDS

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