pep2-AVKI

Name: pep2-AVKI
Brand: Tocris Bioscience
SKU: 1600

Tocris Bioscience, part of Bio-Techne | Catalog # 1600

COA / SDS

Peptide inhibitor of GluA2 subunit binding to PICK1

Discontinued Product

1600 has been discontinued. View all AMPA Receptor Inhibitors products.

Key Product Details

Description:	Peptide inhibitor of GluA2 subunit binding to PICK1
Molecular Weight:	1268.47

View Full Technical Details for pep2-AVKI

Technical Data
Citations

Biological Activity for pep2-AVKI

pep2-AVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).

Technical Data for pep2-AVKI

M. Wt	1268.47
Formula	C₆₀H₉₃N₁₃O₁₇
Single Letter Sequence	YNVYGIEAVKI
Storage	Desiccate at -20°C
CAS Number	1315378-69-8
PubChem ID	90479810
InChi Key	SODUKHPKIVEQLX-OCXIBOJYSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for pep2-AVKI

References are publications that support the biological activity of the product.

Li AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 1999 PMID: 10526335
Hanley NSF ATPase and α-/β-SNAPs disassemble the AMPA receptor-PICK1 complex. Neuron 2002 PMID: 11931741
Kim Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc.Natl.Acad.Sci.U.S.A. 2001 PMID: 11573007
Daw PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 2000 PMID: 11163273

pep2-AVKI

Tocris Bioscience, part of Bio-Techne | Catalog # 1600

Key Product Details

Biological Activity for pep2-AVKI

Technical Data for pep2-AVKI

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for pep2-AVKI

Product Documents for pep2-AVKI

COA

Certificate of Analysis

SDS

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