PD 144418 oxalate

Name: PD 144418 oxalate
Brand: Tocris Bioscience
SKU: 2606

Tocris Bioscience, part of Bio-Techne | Catalog # 2606

Citations (9)

COA / SDS

High affinity, selective σ1 ligand

Discontinued Product

2606 has been discontinued. View all Sigma1 Receptor Ligands products.

Key Product Details

Description:	High affinity, selective σ₁ ligand
Chemical Name:	1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate
Purity:	≥98% (HPLC)
Molecular Weight:	372.42

View Full Technical Details for PD 144418 oxalate

Technical Data
Citations

Biological Activity for PD 144418 oxalate

PD 144418 oxalate is a high affinity, selective σ₁ ligand (K_i values are 0.08 and 1377 nM for σ₁ and σ₂ respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PD 144418 oxalate

PD 144418 oxalate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PD 144418 oxalate

M. Wt	372.42
Formula	C₁₈H₂₂N₂O.C₂H₂O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1794760-28-3
PubChem ID	9817231
InChi Key	FOQRKFCLRMMKAT-UHFFFAOYSA-N
Smiles	O=C(O)C(O)=O.CCCN1CC(C2=CC(C3=CC=C(C)C=C3)=NO2)=CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PD 144418 oxalate

References are publications that support the biological activity of the product.

Lever Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J.Pharmacol.Exp.Ther. 2014 PMID: 25100754
Akunne The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology 1997 PMID: 9144641