Parthenolide

Name: Parthenolide
Brand: tocris
SKU: 0610
Rating: 5 (1 reviews)

Catalog # 0610

Citations (2)

(1)

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Key Product Details

Description:	5-HT release inhibitor
Chemical Name:	[1aR-(1aR,4E,7aS,10aS,-10bR)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Purity:	≥98% (HPLC)

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Biological Activity

The active principle of feverfew (Chrysanthemum parthenium). Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits activation of NF-κB, and generation of leukotriene B₄ and thromboxane B₂.

Compound Libraries

Parthenolide is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	248.32
Formula	C₁₅H₂₀O₃
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	20554-84-1
PubChem ID	6473881
InChi Key	KTEXNACQROZXEV-SLXBATTESA-N
Smiles	C/C1=C\CC[C@]2(C)[C@@H](O2)[C@@H](OC([C@]3=C)=O)[C@H]3CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	12.42	100

Preparing Stock Solutions

The following data is based on the product molecular weight 248.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.03 mL	20.14 mL	40.27 mL
5 mM	0.81 mL	4.03 mL	8.05 mL
10 mM	0.40 mL	2.01 mL	4.03 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

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References

References are publications that support the biological activity of the product.

Groenewegen and Heptinstall A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro. J.Pharm.Pharmacol. 1990 PMID: 1981582
Heptinstall Compounds extracted from feverfew that have anti-secretory activity contain an α-methylene butyrolactone unit. J.Pharm.Pharmacol. 1986 PMID: 2877077
Sumner Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. Biochem.Pharmacol. 1992 PMID: 1319159
Hehner Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β. J.Biol.Chem. 1998 PMID: 9430659

Showing 1-2 of 2 citations

Citations (2)

Citations are publications that use Bio-techne products. Selected citations for Parthenolide include:

Lee et al. (2016) Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. Anesth Analg. 7:11322
PMID: 27089465
Schwarz et al. (2011) Parthenolide Blocks Cocaine's Effect on Spontaneous Firing Activity of DArgic Neurons in the Ventral Tegmental Area. Curr Neuropharmacol. 9:17
PMID: 21886554

There are no citations that match your criteria.

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Parthenolide as a behavioral cocaine antagonist

Name: One Pagan | 10th Jan 2018

Species: Other

Assay Type: In Vivo

Behavioral evaluation of antagonistic effects of parthenolide on cocaine effects in planarians

I have used Tocris’ Parthenolide (Cat. No. 0610) for a few years in my research program searching for behavioral antagonists of cocaine. This research has resulted in 5 peer-reviewed papers and the discovery story is included in a chapter of my book The First Brain: The Neuroscience of Planarians and in a review paper (shown in the figure). There are at least 4 more papers in preparation and the project is still going strong. In the initial phases of my project, I evaluated several suppliers of parthenolide and Tocris’ offering consistently came ahead in terms of customer service and compound purity, and I do not intend to change suppliers. I recommend this product and the company without reservation.

PMID: 22451007, 21886554, 21878350, 18275955, 18222535 Reference

Parthenolide

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Key Product Details

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Biological Activity

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Preparing Stock Solutions

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Dilution Calculator

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References

Citations (2)

Customer Reviews

Parthenolide as a behavioral cocaine antagonist

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