Oleamide

Name: Oleamide
Brand: Tocris Bioscience
SKU: 0878

Catalog # 0878

COA / SDS

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$35 to United States

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Key Product Details

Description:	Sleep-inducing brain lipid
Chemical Name:	cis-9-Octadecenamide
Purity:	≥98%
Molecular Weight:	281.48

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Biological Activity

Oleamide is an endogenous sleep-inducing lipid. Acts as an agonist at the CB₁ cannabinoid receptor (EC₅₀ = 1.64 μM). Also appears to potentiate the actions of 5-HT on 5-HT_2A and _2C receptors, and act via an allosteric regulatory site on 5-HT₇ receptors.

Technical Data

M. Wt	281.48
Formula	C₁₈H₃₅NO
Storage	Store at +4°C
Purity	≥98%
CAS Number	301-02-0
PubChem ID	5283387
InChi Key	FATBGEAMYMYZAF-KTKRTIGZSA-N
Smiles	CCCCCCCC\C=C/CCCCCCCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	28.15	100
	DMSO	14.07	50

Preparing Stock Solutions

The following data is based on the product molecular weight 281.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.55 mL	17.76 mL	35.53 mL
5 mM	0.71 mL	3.55 mL	7.11 mL
10 mM	0.36 mL	1.78 mL	3.55 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

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References

References are publications that support the biological activity of the product.

Leggett Oleamide is a selective endogenous agonist of rat and human CB₁ cannabinoid receptors. Br.J.Pharmacol. 2004 PMID: 14707029
Hedlund Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine₇ receptors. Biochem.Pharmacol. 1999 PMID: 10571256
Huidobro-Toro and Harris Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors. Proc.Natl.Acad.Sci.U.S.A. 1996 PMID: 8755606
Cravatt Chemical characterisation of a family of brain lipids that induces sleep. Science 1995 PMID: 7770779

Citations for Oleamide

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