NU 2058

Name: NU 2058
Brand: Tocris Bioscience
SKU: 3135

Tocris Bioscience a Bio-Techne Brand

Catalog # 3135

Citations (1)

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Key Product Details

Description:	Cdk1 and cdk2 inhibitor
Chemical Name:	6-(Cyclohexylmethoxy)-9H-purin-2-amine
Purity:	≥99% (HPLC)
Molecular Weight:	247.3

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Biological Activity for NU 2058

NU 2058 is a cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (K_i values are 5 and 12 μM respectively). Inhibits growth of human tumor cells in vitro (mean GI₅₀ = 13 μM). Also inhibits DNA topoisomerase II ATPase activity (IC₅₀ = 300 μM).

Technical Data for NU 2058

M. Wt	247.3
Formula	C₁₂H₁₇N₅O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	161058-83-9
PubChem ID	4564
InChi Key	MWGXGTJJAOZBNW-UHFFFAOYSA-N
Smiles	NC1=NC(OCC3CCCCC3)=C2C(NC=N2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NU 2058

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.73	100
	ethanol	2.47	10

Preparing Stock Solutions for NU 2058

The following data is based on the product molecular weight 247.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.04 mL	20.22 mL	40.44 mL
5 mM	0.81 mL	4.04 mL	8.09 mL
10 mM	0.40 mL	2.02 mL	4.04 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

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References for NU 2058

References are publications that support the biological activity of the product.

Jensen Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors. Cancer Res. 2005 PMID: 16103101
Knockaert Pharmacological inhibitors of cyclin-dependent kinases. TiPS 2002 PMID: 12237154
Arris Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J.Med.Chem. 2000 PMID: 10956187

Citations for NU 2058 (1)

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Citations are publications that use Bio-Techne products. Selected citations for NU 2058 include:

Goonesekere et al. (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One. 9:e93046
PMID: 24740004

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