NSC 693868

Name: NSC 693868
Brand: Tocris Bioscience
SKU: 1937

Tocris Bioscience a Bio-Techne Brand

Catalog # 1937

COA / SDS

Discontinued Product

1937 has been discontinued. View all Cyclin-dependent Kinase Inhibitors products.

Key Product Details

Description:	Cdk inhibitor; also inhibits GSK-3
Chemical Name:	1H-Pyrazolo[3,4-b]quinoxalin-3-amine
Purity:	≥99% (HPLC)
Molecular Weight:	185.19

View Full Technical Details for NSC 693868

Biological Activity for NSC 693868

Cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.4, 0.6, 4.4 - 5.6 μM for cdk5, cdk1 and cdk2, respectively). Also inhibits GSK-3 (IC₅₀ = 1 _uM).

Technical Data for NSC 693868

M. Wt	185.19
Formula	C₉H₇N₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	40254-90-8
PubChem ID	438981
InChi Key	DWHVZCLBMTZRQM-UHFFFAOYSA-N
Smiles	NC1=NN=C2NC3=CC=CC=C3N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NSC 693868

Solubility

Soluble Soluble to 100 mM in DMSO

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References for NSC 693868

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Ortega Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg.Med.Chem.Lett. 2002 PMID: 11983514
Monge 3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity. J.Heterocycl.Chem.

Citations for NSC 693868

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