NSC 693868

Name: NSC 693868
Brand: Tocris Bioscience
SKU: 1937

Tocris Bioscience, part of Bio-Techne | Catalog # 1937

COA / SDS

Cdk inhibitor; also inhibits GSK-3

Discontinued Product

1937 has been discontinued. View all Cyclin-dependent Kinase Inhibitors products.

Key Product Details

Description:	Cdk inhibitor; also inhibits GSK-3
Chemical Name:	1H-Pyrazolo[3,4-b]quinoxalin-3-amine
Purity:	≥99% (HPLC)
Molecular Weight:	185.19

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Technical Data
Citations

Biological Activity for NSC 693868

Cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.4, 0.6, 4.4 - 5.6 μM for cdk5, cdk1 and cdk2, respectively). Also inhibits GSK-3 (IC₅₀ = 1 _uM).

Technical Data for NSC 693868

M. Wt	185.19
Formula	C₉H₇N₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	40254-90-8
PubChem ID	438981
InChi Key	DWHVZCLBMTZRQM-UHFFFAOYSA-N
Smiles	NC1=NN=C2NC3=CC=CC=C3N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NSC 693868

References are publications that support the biological activity of the product.

Monge 3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity. J.Heterocycl.Chem.
Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Ortega Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg.Med.Chem.Lett. 2002 PMID: 11983514

NSC 693868

Tocris Bioscience, part of Bio-Techne | Catalog # 1937

Key Product Details

Biological Activity for NSC 693868

Technical Data for NSC 693868

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for NSC 693868

Product Documents for NSC 693868

COA

Certificate of Analysis

SDS

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