NSC 66811

Name: NSC 66811
Brand: Tocris Bioscience
SKU: 2936

Tocris Bioscience, part of Bio-Techne | Catalog # 2936

COA / SDS

MDM2 antagonist. Disrupts MDM2-p53 interaction

Discontinued Product

2936 has been discontinued. View all p53 Activators products.

Key Product Details

Description:	MDM2 antagonist. Disrupts MDM2-p53 interaction
Chemical Name:	2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
Purity:	≥97% (HPLC)
Molecular Weight:	340.42

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Technical Data
Citations

Biological Activity for NSC 66811

Potent MDM2 inhibitor (K_i = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.

Technical Data for NSC 66811

M. Wt	340.42
Formula	C₂₃H₂₀N₂O
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	6964-62-1
PubChem ID	248986
InChi Key	WEENRMPCSWFMTE-UHFFFAOYSA-N
Smiles	CC2=NC1=C(O)C(C(NC4=CC=CC=C4)C3=CC=CC=C3)=CC=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NSC 66811

References are publications that support the biological activity of the product.

Shangary and Shaomeng Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Ann.Rev.Pharmacol.Toxicol.
Lu Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J.Med.Chem. 2006 PMID: 16789731

NSC 66811

Tocris Bioscience, part of Bio-Techne | Catalog # 2936

Key Product Details

Biological Activity for NSC 66811

Technical Data for NSC 66811

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for NSC 66811

Product Documents for NSC 66811

COA

Certificate of Analysis

SDS

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