NSC 146109 hydrochloride

Name: NSC 146109 hydrochloride
Brand: Tocris Bioscience
SKU: 2185
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2185

(1)

Citations (6)

COA / SDS

Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription

Discontinued Product

2185 has been discontinued. View all p53 Activators products.

Key Product Details

Description:	Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
Chemical Name:	(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	316.85

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Technical Data
Citations / Reviews (1)

Biological Activity for NSC 146109 hydrochloride

NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.

Technical Data for NSC 146109 hydrochloride

M. Wt	316.85
Formula	C₁₇H₁₆N₂S.HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	59474-01-0
PubChem ID	5458312
InChi Key	VIBMUYOXJUCEMA-UHFFFAOYSA-N
Smiles	N=C(N)SCC1=C(C=CC=C3)C3=C(C)C2=C1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NSC 146109 hydrochloride

References are publications that support the biological activity of the product.

Berkson Pilot screening programme for small molecule activators of p53. Int.J.Cancer 2005 PMID: 15729694
Dolma Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 2003 PMID: 12676586

NSC 146109 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2185

Key Product Details

Biological Activity for NSC 146109 hydrochloride

Technical Data for NSC 146109 hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for NSC 146109 hydrochloride

Product Documents for NSC 146109 hydrochloride

COA

Certificate of Analysis

SDS

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