Nitrendipine

Name: Nitrendipine
Brand: Tocris Bioscience
SKU: 0601
Rating: 5 (1 reviews)

Catalog # 0601

Citations (3)

(1)

COA / SDS

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Key Product Details

Description:	Ca_V1.x blocker
Chemical Name:	1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylic acid ethyl methyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	360.37

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Biological Activity

Nitrendipine is a L-type calcium channel blocker. Induces autophagy.

Technical Data

M. Wt	360.37
Formula	C₁₈H₂₀N₂O₆
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	39562-70-4
PubChem ID	4507
InChi Key	PVHUJELLJLJGLN-UHFFFAOYSA-N
Smiles	CCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mM
Solubility
	DMSO	50
	ethanol	25

Preparing Stock Solutions

The following data is based on the product molecular weight 360.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.55 mL	27.75 mL	55.50 mL
2.5 mM	1.11 mL	5.55 mL	11.10 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
25 mM	0.11 mL	0.55 mL	1.11 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Fleming Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 2011 PMID: 21164513
Costa Characterization of a voltage-dependent L-type calcium channel from rabbit and turtle brain. Neurochem.Res. 1996 PMID: 8726959
Watanabe L-type calcium channel block by highly hydrophilic dihydropyridines in single ventricular cells of guinea-pig hearts. J.Mol.Cell.Cardiol. 1995 PMID: 8531209

Citations for Nitrendipine (3)

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Citations are publications that use Bio-Techne products. Selected citations for Nitrendipine include:

Subramanian and Morozov (2011) Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels. J Neurosci. 31:4755
PMID: 21430174
Rosenkranz et al. (2009) Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT. Cardiovasc Res. 83:778
PMID: 19460777
Schmitz et al. (2009) Glutamate controls growth rate and branching of DArgic axons. J Neurosci. 29:11973
PMID: 19776283

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Nitrendipine was measured against other calcium channel blockers

Name: Anonymous

Species: Human

Nitrendipine blocks L-type calcium channels in smooth muscle cells and its effectiveness was measured against other calcium channel blockers.

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