Neuropeptide SF (mouse, rat)

Name: Neuropeptide SF (mouse, rat)
Brand: Tocris Bioscience
SKU: 3647

Tocris Bioscience, part of Bio-Techne | Catalog # 3647

COA / SDS

NPFF1 and NPFF2 agonist

Discontinued Product

3647 has been discontinued. View all Neuropeptide FF/AF Receptor Agonists products.

Key Product Details

Description:	NPFF1 and NPFF2 agonist
Molecular Weight:	888.03

View Full Technical Details for Neuropeptide SF (mouse, rat)

Technical Data
Citations

Biological Activity for Neuropeptide SF (mouse, rat)

Neuropeptide SF (mouse, rat) is a neuropeptide FF receptor agonist (K_i values are 48.4 and 12.1 nM for NPFF1 and NPFF2, respectively). Potentiates the antinociceptive action of morphine in vivo and reverses the loss of morphine potency in tolerant animals. Also increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) (EC₅₀ ~ 50 μM).

Technical Data for Neuropeptide SF (mouse, rat)

M. Wt	888.03
Formula	C₄₀H₆₅N₁₃O₁₀
Single Letter Sequence	SLAAPQRF (Modifications: Phe-8 = C-terminal amide)
Storage	Store at -20°C
CAS Number	230960-31-3
PubChem ID	90488868
InChi Key	OLOSAWFREOVGQW-CJKZIAQFSA-N
Smiles	[H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Neuropeptide SF (mouse, rat)

References are publications that support the biological activity of the product.

Jhamandas Facilitation of spinal mor. analgesia in normal and mor. tolerant animals by neuropeptide SF and related peptides. Peptides 2006 PMID: 16515821
Gouarderes Quantitative autoradiographic distribution of NPFF₁ neuropeptide FF receptor in the rat brain and comparison with NPFF₂ receptor by using [¹²⁵I]YVP and [¹²⁵I]EYF as selective radioligands. Neurosci.
Deval Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Neuropharmacology 2003 PMID: 12668052

Neuropeptide SF (mouse, rat)

Tocris Bioscience, part of Bio-Techne | Catalog # 3647

Key Product Details

Biological Activity for Neuropeptide SF (mouse, rat)

Technical Data for Neuropeptide SF (mouse, rat)

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Neuropeptide SF (mouse, rat)

Product Documents for Neuropeptide SF (mouse, rat)

COA

Certificate of Analysis

SDS

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