NCS-382

Name: NCS-382
Brand: tocris
SKU: 0780

Catalog # 0780

Datasheet / COA / SDS

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Key Product Details

Description:	Antagonist of γ-hydroxybutyric acid
Chemical Name:	6,7,8,9-Tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylideneacetic acid
Purity:	≥99% (HPLC)
Molecular Weight:	218.25

View Full Technical Details for NCS-382

Technical Data
Citations / Reviews

Biological Activity

γ-Hydroxybutyric acid antagonist, anticonvulsant.

Technical Data

M. Wt	218.25
Formula	C₁₃H₁₄O₃
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	520505-01-5
PubChem ID	5875451
InChi Key	UADPGHINQMWEAG-CSKARUKUSA-N
Smiles	OC1C2=C(CCC\C1=C/C(O)=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.83	100

Preparing Stock Solutions

The following data is based on the product molecular weight 218.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.58 mL	22.91 mL	45.82 mL
5 mM	0.92 mL	4.58 mL	9.16 mL
10 mM	0.46 mL	2.29 mL	4.58 mL
50 mM	0.09 mL	0.46 mL	0.92 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

King Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice. J.Neural Transm. 1997 PMID: 9503264
Maitre A specific γ-hydroxybutyrate receptor ligand possesses both antagonist and anticonvulsant properties. J.Pharmacol.Exp.Ther. 1990 PMID: 2173754
Schmidt Anti-sedative and anti-cataleptic properties of NCS-382, a γ-hydroxybutyrate receptor antagonist. Eur.J.Pharmacol. 1991 PMID: 1773824

Citations

Currently there are no citations for NCS-382.

Product Datasheets

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.

SDS

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