Myricetin

Name: Myricetin
Brand: Tocris Bioscience
SKU: 6189

Tocris Bioscience, part of Bio-Techne | Catalog # 6189

COA / SDS

Irreversible TrxR inhibitor

Discontinued Product

6189 has been discontinued. View all Other Reductase Inhibitors products.

Key Product Details

Description:	Irreversible TrxR inhibitor
Chemical Name:	3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
Purity:	≥97% (HPLC)
Molecular Weight:	318.24

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Technical Data
Citations

Biological Activity for Myricetin

Myricetin is an irreversible TrxR inhibitor (IC₅₀ = 0.62 μM). Exhibits concentration-, time- and NADH-dependent TrxR inhibition. Results in the oxidation of Trx and reduced TrxR activity in vitro in addition to the accumulation of cells in sub-G₁ phase. Reduces neoplastic transformation and induces cell death in cancer cell lines. Chemotherapeutic. Myricetin binds to the CAG motif of the mutant RNA from the HTT gene in Huntington's disease (HD). It prevents the translation of mutant huntingtin protein as well as sequestration of MBNL1. Myricetin alleviates proteotoxicity of expanded polyglutamine proteins in Cos-7 cells. Myricetin also improves neurobehavioral deficits in the HD mouse model.

Technical Data for Myricetin

M. Wt	318.24
Formula	C₁₅H₁₀O₈
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	529-44-2
PubChem ID	5281672
InChi Key	IKMDFBPHZNJCSN-UHFFFAOYSA-N
Smiles	OC1=CC(O)=C2C(OC(C3=CC(O)=C(C(O)=C3)O)=C(C2=O)O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Myricetin

References are publications that support the biological activity of the product.

Khan Myricetin reduces toxic level of CAG repeats RNA in Huntington's Disease (HD) and Spino Cerebellar Ataxia (SCAs). ACS Chem.Biol. 2018 PMID: 29172480
Ong & Khoo Biological effects of myricetin. Gen.Pharmacol. 1997 PMID: 9251891
Devi Molecular mechanisms underlying anticancer effects of myricetin. Life.Sci. 2015 PMID: 26455550
Ko Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade. Biochem.Pharmacol. 2005 PMID: 15748703
Lu & Holmgren Selenoproteins. J.Biol.Chem. 2009 PMID: 18757362
Lu Inhibition of mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer.Res. 2006 PMID: 16618767

Myricetin

Tocris Bioscience, part of Bio-Techne | Catalog # 6189

Key Product Details

Biological Activity for Myricetin

Technical Data for Myricetin

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Myricetin

Product Documents for Myricetin

COA

Certificate of Analysis

SDS

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