MSG 606

Name: MSG 606
Brand: Tocris Bioscience
SKU: 5954

Tocris Bioscience, part of Bio-Techne | Catalog # 5954

COA / SDS

Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist

Discontinued Product

5954 has been discontinued. View all Melanocortin Receptor Antagonists products.

Key Product Details

Description:	Potent human MC₁ receptor antagonist; also MC₃ and MC₅ partial agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1347.51

View Full Technical Details for MSG 606

Technical Data
Citations

Biological Activity for MSG 606

MSG 606 is a potent human MC₁ receptor antagonist (IC₅₀ = 17 nM). Also partial agonist at human MC₃ and MC₅ receptors (EC₅₀ values are 59 and 1300 nM, respectively). Exhibits binding affinity for A375 melanoma cells in vitro. Reverses morphine-induced hyperalgesia in female mice, with no effect in male mice. γMSH analog.

Technical Data for MSG 606

M. Wt	1347.51
Formula	C₆₂H₈₂N₂₀O₁₃S
Single Letter Sequence	XGHFRWCDRFG (Modifications: X = Butanoic acid, Phe-4 = D-Phe, Trp-6 = D-Trp, Gly-11 = C-terminal amide, Carba sulfide bridge: X-1 - Cys-7)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1416983-77-1
PubChem ID	122177131
InChi Key	QJBNFEXQHBDMQM-VTWSTLNFSA-N
Smiles	NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CSCCCC(=O)NCC(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for MSG 606

References are publications that support the biological activity of the product.

Juni Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. Anesthesiology 2010 PMID: 19996949
Arout Spinal and supraspinal N-methyl-D-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia. Physiol.Behav. 2015 PMID: 25982086
Cai An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells. Biochemistry 2013 PMID: 23276279

MSG 606

Tocris Bioscience, part of Bio-Techne | Catalog # 5954

Key Product Details

Biological Activity for MSG 606

Technical Data for MSG 606

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for MSG 606

Product Documents for MSG 606

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected