MMK 1

Name: MMK 1
Brand: Tocris Bioscience
SKU: 3537
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3537

(1)

Citations (13)

COA / SDS

Potent and selective FPR2 agonist

Discontinued Product

3537 has been discontinued. View all Formyl Peptide Receptor Agonists products.

Key Product Details

Description:	Potent and selective FPR2 agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1610.97

View Full Technical Details for MMK 1

Technical Data
Citations / Reviews (1)

Biological Activity for MMK 1

MMK 1 is a potent and selective human formyl peptide receptor FPR2 agonist (EC₅₀ values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.

DMSO is not recommended as a solvent for this peptide.

Technical Data for MMK 1

M. Wt	1610.97
Formula	C₇₅H₁₂₃N₁₉O₁₈S
Single Letter Sequence	LESIFRSLLFRVM
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	271246-66-3
PubChem ID	25074458
InChi Key	PWBQRCXCXXGUGY-AJOXZCOLSA-N
Smiles	[H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for MMK 1

References are publications that support the biological activity of the product.

Klein Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nature Biotech.
Hu Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1. J.Leukoc.Biol. 2001 PMID: 11435499

MMK 1

Tocris Bioscience, part of Bio-Techne | Catalog # 3537

Key Product Details

Biological Activity for MMK 1

Technical Data for MMK 1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for MMK 1

Product Documents for MMK 1

COA

Certificate of Analysis

SDS

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