MK 0343

Name: MK 0343
Brand: Tocris Bioscience
SKU: 4415

Tocris Bioscience, part of Bio-Techne | Catalog # 4415

COA / SDS

GABAA partial agonist; displays subtype selectivity

Discontinued Product

4415 has been discontinued. View all GABA-A Receptor Agonists products.

Key Product Details

Description:	GABA_A partial agonist; displays subtype selectivity
Chemical Name:	7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazo[4,3-b]pyridazine
Purity:	≥99% (HPLC)
Molecular Weight:	397.38

View Full Technical Details for MK 0343

Technical Data
Citations

Biological Activity for MK 0343

MK 0343 is a subtype-selective GABA_A partial agonist (K_i values are 0.21, 0.22, 0.23 and 0.40 for α3, α1, α5 and α2 respectively); occupies the benzodiazepine site of GABA_A receptors. Displays greater agonist efficacy at α3 compared to α1. Exhibits anxiolytic and non-sedating properties in rodent models. Brain penetrant.

Technical Data for MK 0343

M. Wt	397.38
Formula	C₁₉H₁₇F₂N₇O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	233275-76-8
PubChem ID	22609888
InChi Key	GOIFCXRIFSYPFG-UHFFFAOYSA-N
Smiles	FC(C=CC=C3F)=C3C1=NN=C2N1N=C(OCC5=NC=NN5C)C(C4CCC4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for MK 0343

References are publications that support the biological activity of the product.

de Haas Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA_A α_2,3 subtype-selective agonist, compared to L.pam and placebo in healthy male volunteers. J.Psychopharmacol. 2008 PMID: 18187530
Atack Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, prima J.Pharmacol.Exp.Ther.
Atack MRK-409 (MK-0343), a GABA_A receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans. J.Psychopharmacol. 2011 PMID: 20147571

MK 0343

Tocris Bioscience, part of Bio-Techne | Catalog # 4415

Key Product Details

Biological Activity for MK 0343

Technical Data for MK 0343

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References for MK 0343

Product Documents for MK 0343

COA

Certificate of Analysis

SDS

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