MDL 11,939

Name: MDL 11,939
Brand: Tocris Bioscience
SKU: 0870
Rating: 5 (1 reviews)

Catalog # 0870

Citations (7)

(1)

COA / SDS

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Key Product Details

Description:	5-HT_2A antagonist
Chemical Name:	α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
Purity:	≥99% (HPLC)
Molecular Weight:	295.42

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Biological Activity

MDL 11,939 is an orally active 5-HT_2A receptor antagonist; displays selectivity for 5-HT_2A receptors over 5-HT_2C receptors (K_i values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT_2A, human 5-HT_2A, rabbit 5-HT_2C and human 5-HT_2C receptors respectively).

Technical Data

M. Wt	295.42
Formula	C₂₀H₂₅NO
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	107703-78-6
PubChem ID	71781
InChi Key	AXNGJCOYCMDPQG-UHFFFAOYSA-N
Smiles	OC(C1CCN(CCC2=CC=CC=C2)CC1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	14.77	50
	DMSO	14.77	50

Preparing Stock Solutions

The following data is based on the product molecular weight 295.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.77 mL	33.85 mL	67.70 mL
2.5 mM	1.35 mL	6.77 mL	13.54 mL
5 mM	0.68 mL	3.39 mL	6.77 mL
25 mM	0.14 mL	0.68 mL	1.35 mL

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References

References are publications that support the biological activity of the product.

Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
Aloyo and Harvey Antagonist binding at 5-HT_2A and 5-HT_2C receptors in the rabbit: high correlation with the profile for the human receptors. Eur.J.Pharmacol. 2000 PMID: 11020478
Dudley Pharmacological effects of MDL 11,939: a selective, centrally acting antagonist of 5-HT₂ receptors. Drug Dev.Res.

Citations for MDL 11,939 (7)

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Citations are publications that use Bio-Techne products. Selected citations for MDL 11,939 include:

Corcoran et al. (2014) Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. J Neurosci. 34:51
PMID: 24381267
Goda et al. (2013) Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl). 228:271
PMID: 23525524
Williams et al. (2012) Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by cloz. Neuropsychopharmacology. 37:2285
PMID: 22692564
Halberstadt and Geyer (2010) LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor. Psychopharmacology (Berl). 208:179
PMID: 19937319
Yu and Yamaguchi (2009) 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. J Neurophysiol. 102:752
PMID: 19474172
Ptak et al. (2009) Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. Biomol Ther (Seoul). 29:3720
PMID: 19321769
Hodges et al. (2009) Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development. J Neurosci. 29:10341
PMID: 19692608

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we used it for in vivo infusions

Name: noelia weisstaub

Species: Rat

Assay Type: In Vivo

We used MDL for in vivo infusion at different regions of the brain. It works very well. It is very stable and easy to dissolve and not sticky which make it easy to infuse.

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