MDL 11,939
Tocris Bioscience, part of Bio-Techne | Catalog # 0870
5-HT2A antagonist
Product Description
MDL 11,939 is an orally active 5-HT2A receptor antagonist; displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively).Product Specifications
Molecular Weight
295.42
Formula
C20H25NO
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
CAS Number
107703-78-6
PubChem ID
71781
InChI Key
AXNGJCOYCMDPQG-UHFFFAOYSA-N
SMILES
OC(C1CCN(CCC2=CC=CC=C2)CC1)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.77 | 50 | |
| Ethanol | 14.77 | 50 |
Preparing Stock Solutions
for MDL 11,939
The following data is based on the product molecular weight 295.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.77 mL | 33.85 mL | 67.70 mL |
| 2.5 mM | 1.35 mL | 6.77 mL | 13.54 mL |
| 5 mM | 0.68 mL | 3.39 mL | 6.77 mL |
| 25 mM | 0.14 mL | 0.68 mL | 1.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dudley Pharmacological effects of MDL 11,939: a selective, centrally acting antagonist of 5-HT2 receptors. Drug Dev.Res.
- Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
- Aloyo and Harvey Antagonist binding at 5-HT2A and 5-HT2C receptors in the rabbit: high correlation with the profile for the human receptors. Eur.J.Pharmacol. 2000 PMID: 11020478
Product Specific Notices for MDL 11,939
For research use only
Loading...
Loading...
Loading...